Term Details for "MAPK cascade" (GO:0000165) (original) (raw)
Accession
GO:0000165
Name
MAPK cascade
Ontology
biological_process
Synonyms
MAP kinase cascade, MAP kinase kinase kinase cascade, MAPK signal transduction, MAPKKK cascade, mitogen-activated protein kinase cascade, MAPK signaling, MAPK signalling, ERK/MAPK cascade, MAPKKK cascade during sporulation
Alternate IDs
GO:0007255
Definition
An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.Source: PMID:9561267,PMID:20811974
Comment
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
History
See term history for GO:0000165 at QuickGO
Chem. react.
None
Subset
None
Link to all genes and gene products annotated to MAPK cascade (excluding "regulates").
Link to all direct and indirect annotations to MAPK cascade (excluding "regulates").
Link to all direct and indirect annotations download (limited to first 10,000) for MAPK cascade (excluding "regulates").