Term Details for "signal transduction" (GO:0007165) (original) (raw)

Accession

GO:0007165

Name

signal transduction

Ontology

biological_process

Synonyms

signaling pathway, signalling pathway, signaling cascade, signalling cascade

Alternate IDs

GO:0023016, GO:0023014, GO:0023015, GO:0023045, GO:0023033

Definition

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.Source: GOC:mtg_signaling_feb11,GOC:go_curators

Comment

Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.

History

See term history for GO:0007165 at QuickGO

Chem. react.

None

Subset

goslim_metagenomics

goslim_chembl

goslim_plant

goslim_plant_ribbon

goslim_candida

Link to all genes and gene products annotated to signal transduction (excluding "regulates").

Link to all direct and indirect annotations to signal transduction (excluding "regulates").

Link to all direct and indirect annotations download (limited to first 10,000) for signal transduction (excluding "regulates").