Term Details for "canonical NF-kappaB signal transduction" (GO:0007249) (original) (raw)

Accession

GO:0007249

Name

canonical NF-kappaB signal transduction

Ontology

biological_process

Synonyms

I-kappaB kinase/NF-kappaB cascade, I-kappaB kinase/NF-kappaB signal transduction, I-kappaB kinase/NF-kappaB signaling, canonical NF-kappaB signaling cascade, p50-dependent NF-kappaB signaling, NF-kappaB cascade

Alternate IDs

None

Definition

An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs).Source: PMID:12773372,PMID:34659217,GOC:bf

Comment

None

History

See term history for GO:0007249 at QuickGO

Chem. react.

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Subset

None

Link to all genes and gene products annotated to canonical NF-kappaB signal transduction (excluding "regulates").

Link to all direct and indirect annotations to canonical NF-kappaB signal transduction (excluding "regulates").

Link to all direct and indirect annotations download (limited to first 10,000) for canonical NF-kappaB signal transduction (excluding "regulates").