Term Details for "non-canonical NF-kappaB signal transduction" (GO:0038061) (original) (raw)

Accession

GO:0038061

Name

non-canonical NF-kappaB signal transduction

Ontology

biological_process

Synonyms

NIK-IKK kinase cascade, NIK-IKK signaling pathway, NIK-IKK-alpha cascade, NIK/NF-kappaB cascade, NIK/NF-kappaB signal transduction, NIK/NF-kappaB signaling, non-canonical NF-KB signaling, noncanonical NF-kappaB signaling, noncanonical nuclear factor kappaB (NF-kappaB) pathway, p52-dependent NF-kappaB signaling, NF-kappaB cascade

Alternate IDs

None

Definition

An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF).Source: GOC:signaling,PMID:15140882,GOC:vs,PMID:34659217,PMID:11239468,GOC:bf,GOC:mg2

Comment

None

History

See term history for GO:0038061 at QuickGO

Chem. react.

None

Subset

None

Link to all genes and gene products annotated to non-canonical NF-kappaB signal transduction (excluding "regulates").

Link to all direct and indirect annotations to non-canonical NF-kappaB signal transduction (excluding "regulates").

Link to all direct and indirect annotations download (limited to first 10,000) for non-canonical NF-kappaB signal transduction (excluding "regulates").