Term Details for "vascular endothelial growth factor receptor signaling pathway" (GO:0048010) (original) (raw)
Accession
GO:0048010
Name
vascular endothelial growth factor receptor signaling pathway
Ontology
biological_process
Synonyms
VEGF receptor signaling pathway, VEGF receptor signalling pathway, VEGFR signaling pathway
Alternate IDs
None
Definition
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.Source: GOC:signaling,GOC:ceb
Comment
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
History
See term history for GO:0048010 at QuickGO
Chem. react.
None
Subset
None
Link to all genes and gene products annotated to vascular endothelial growth factor receptor signaling pathway (excluding "regulates").
Link to all direct and indirect annotations to vascular endothelial growth factor receptor signaling pathway (excluding "regulates").
Link to all direct and indirect annotations download (limited to first 10,000) for vascular endothelial growth factor receptor signaling pathway (excluding "regulates").