SCRIP: An Accurate Simulator for Single-Cell RNA Sequencing Data (original) (raw)
We provide a comprehensive scheme that is capable of simulating Single Cell RNA Sequencing data for various parameters of Biological Coefficient of Variation, busting kinetics, differential expression (DE), cell or sample groups, cell trajectory, batch effect and other experimental designs. 'SCRIP' proposed and compared two frameworks with Gamma-Poisson and Beta-Gamma-Poisson models for simulating Single Cell RNA Sequencing data. Other reference is available in Zappia et al. (2017) <https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1305-0>.
| Version: | 1.0.0 |
|---|---|
| Depends: | R (≥ 4.0) |
| Imports: | splatter (≥ 1.16.1), S4Vectors (≥ 0.30.0), SummarizedExperiment (≥ 1.22.0), SingleCellExperiment (≥ 1.14.1), edgeR (≥ 3.34.0), methods, stats, mgcv, knitr, BiocManager, BiocGenerics, Seurat, crayon, fitdistrplus, checkmate (≥ 2.0.0) |
| Suggests: | rmarkdown, testthat (≥ 3.0.0) |
| Published: | 2021-11-19 |
| DOI: | 10.32614/CRAN.package.SCRIP |
| Author: | Fei Qin [aut, cre, cph] |
| Maintainer: | Fei Qin |
| License: | GPL-3 |
| URL: | https://github.com/thecailab/SCRIP |
| NeedsCompilation: | no |
| Language: | en-GB |
| CRAN checks: | SCRIP results [issues need fixing before 2025-06-17] |
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