| dbo:abstract |
1-Pyrroline-5-carboxylic acid (systematic name 3,4-dihydro-2H-pyrrole-2-carboxylic acid) is a cyclic imino acid. Its conjugate base and anion is 1-pyrroline-5-carboxylate (P5C). In solution, P5C is in spontaneous equilibrium with glutamate-5-semialdhyde (GSA). The stereoisomer (S)-1-pyrroline-5-carboxylate (also referred to as L-P5C) is an intermediate metabolite in the biosynthesis and degradation of proline and arginine. In prokaryotic proline biosynthesis, GSA is synthesized from by the enzyme . In most eukaryotes, GSA is synthesised from the amino acid glutamate by the bifunctional enzyme (P5CS). The human P5CS is encoded by the ALDH18A1 gene. The enzyme pyrroline-5-carboxylate reductase converts P5C into proline In proline degradation, the enzyme proline dehydrogenase produces P5C from proline, and the enzyme 1-pyrroline-5-carboxylate dehydrogenase converts GSA to glutamate. In many prokaryotes, proline dehydrogenase and P5C dehydrogenase form a bifunctional enzyme that prevents the release of P5C during proline degradation. In arginine degradation, the enzyme ornithine-δ-aminotransferase mediates the transamination between ornithine and a 2-oxo acid (typically α-ketoglutarate) to form P5C and an L-amino acid (typically glutamate). Under specific conditions, P5C may also be used for arginine biosynthesis via the reverse reaction of ornithine-δ-aminotransferase. (en) L’acide 1-pyrroline-5-carboxylique, ou acide δ-1-pyrroline-5-carboxylique, est un acide iminé dont l'énantiomère S est produit à partir de la proline par la (EC 1.5.1.2) et est converti en glutamate par la (EC 1.5.1.12). (fr) 1-피롤린-5-카복실산(영어: 1-pyrroline-5-carboxylic acid)은 프롤린의 대사 과정에서의 대사 중간생성물인 이미노산이다. 프롤린의 생합성 과정에서 1-피롤린-5-카복실산은 에 의해 프롤린으로 전환된다. 1-피롤린-5-카복실산은 프롤린의 이화 대사 경로에서 프롤린 산화효소에 의해 프롤린으로부터 생성된다. 1-피롤린-5-카복실산은 비효소적으로 글루탐산 γ-세미알데하이드로 전환된 후 글루탐산 세미알데하이드 탈수소효소에 의해 글루탐산으로 전환된다. (ko) 1-ピロリン-5-カルボン酸(1-Pyrroline-5-carboxylic acid)またはP5Cは、イミノ酸である。立体異性体(S)-1-ピロリン-5-カルボン酸は、ピロリン-5-カルボン酸レダクターゼによってプロリンから作られる代謝物質であり、1-ピロリン-5-カルボン酸デヒドロゲナーゼによってグルタミン酸に変換される。 (ja) |
| dbo:alternativeName |
P5C (en) δ-1-Pyrroline-5-carboxylic acid (en) 1-Pyrroline-5-carboxylic acid (en) |
| dbo:iupacName |
3,4-Dihydro-2H-pyrrole-2-carboxylic acid (en) |
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Delta-1-pyrroline-5-carboxylic acid.svg (en) |
| dbp:othernames |
1 (xsd:integer) P5C (en) δ-1-Pyrroline-5-carboxylic acid (en) |
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dbc:Carboxylic_acids dbc:Pyrrolines |
| gold:hypernym |
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| rdfs:comment |
L’acide 1-pyrroline-5-carboxylique, ou acide δ-1-pyrroline-5-carboxylique, est un acide iminé dont l'énantiomère S est produit à partir de la proline par la (EC 1.5.1.2) et est converti en glutamate par la (EC 1.5.1.12). (fr) 1-피롤린-5-카복실산(영어: 1-pyrroline-5-carboxylic acid)은 프롤린의 대사 과정에서의 대사 중간생성물인 이미노산이다. 프롤린의 생합성 과정에서 1-피롤린-5-카복실산은 에 의해 프롤린으로 전환된다. 1-피롤린-5-카복실산은 프롤린의 이화 대사 경로에서 프롤린 산화효소에 의해 프롤린으로부터 생성된다. 1-피롤린-5-카복실산은 비효소적으로 글루탐산 γ-세미알데하이드로 전환된 후 글루탐산 세미알데하이드 탈수소효소에 의해 글루탐산으로 전환된다. (ko) 1-ピロリン-5-カルボン酸(1-Pyrroline-5-carboxylic acid)またはP5Cは、イミノ酸である。立体異性体(S)-1-ピロリン-5-カルボン酸は、ピロリン-5-カルボン酸レダクターゼによってプロリンから作られる代謝物質であり、1-ピロリン-5-カルボン酸デヒドロゲナーゼによってグルタミン酸に変換される。 (ja) 1-Pyrroline-5-carboxylic acid (systematic name 3,4-dihydro-2H-pyrrole-2-carboxylic acid) is a cyclic imino acid. Its conjugate base and anion is 1-pyrroline-5-carboxylate (P5C). In solution, P5C is in spontaneous equilibrium with glutamate-5-semialdhyde (GSA). The stereoisomer (S)-1-pyrroline-5-carboxylate (also referred to as L-P5C) is an intermediate metabolite in the biosynthesis and degradation of proline and arginine. (en) |
| rdfs:label |
1-Pyrroline-5-carboxylic acid (en) Acide 1-pyrroline-5-carboxylique (fr) 1-피롤린-5-카복실산 (ko) 1-ピロリン-5-カルボン酸 (ja) |
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