11α-Hydroxyprogesterone (original) (raw)
11α-羟孕酮（英語：11α-Hydroxyprogesterone，缩写 11α-OHP，或称为11α-羟基孕甾-4-烯-3,20-二酮，11α-hydroxypregn-4-ene-3,20-dione）是一种内源性甾体和孕酮的代谢产物，是一种弱的抗雄激素，缺乏雄激素、雌激素和孕激素活性。 11α-OHP也是可的松与氢化可的松化学合成的前体物质 。
| Property | Value |
|---|---|
| dbo:abstract | 11α-Hydroxyprogesterone (11α-OHP), or 11α-hydroxypregn-4-ene-3,20-dione is an endogenous steroid and metabolite of progesterone. It is a weak antiandrogen, and is devoid of androgenic, estrogenic, and progestogenic activity. 11α-OHP was investigated as a topical antiandrogen for the treatment of androgen-dependent skin conditions in the early 1950s, and was found to produce some benefit. In 1995, 11α-OHP, along with its epimer 11β-hydroxyprogesterone, was identified as a very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of 11β-HSD than enoxolone (glycyrrhetinic acid) or carbenoxolone in vitro (IC50 = 0.9 nM; IC50 = 5 nM in transfected cells). The compound has been found to be highly active in conferring mineralocorticoid sodium-retaining activity of corticosterone in vivo in rat bioassays and in increasing blood pressure, effects that it mediates by preventing the 11β-HSD-mediated inactivation of endogenous corticosteroids. Because of its inhibition of 11β-HSD and consequent potentiation of corticosteroids, 11α-OHP has recently been patented for the treatment of skin diseases, particularly psoriasis in combination with clobetasol propionate and minoxidil. 11α-OHP is used as a precursor in chemical syntheses of cortisone and hydrocortisone. (en) 11α-羟孕酮（英語：11α-Hydroxyprogesterone，缩写 11α-OHP，或称为11α-羟基孕甾-4-烯-3,20-二酮，11α-hydroxypregn-4-ene-3,20-dione）是一种内源性甾体和孕酮的代谢产物，是一种弱的抗雄激素，缺乏雄激素、雌激素和孕激素活性。 11α-OHP也是可的松与氢化可的松化学合成的前体物质 。 (zh) |
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| dbo:pubchem | 92730 |
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| rdfs:comment | 11α-羟孕酮（英語：11α-Hydroxyprogesterone，缩写 11α-OHP，或称为11α-羟基孕甾-4-烯-3,20-二酮，11α-hydroxypregn-4-ene-3,20-dione）是一种内源性甾体和孕酮的代谢产物，是一种弱的抗雄激素，缺乏雄激素、雌激素和孕激素活性。 11α-OHP也是可的松与氢化可的松化学合成的前体物质 。 (zh) 11α-Hydroxyprogesterone (11α-OHP), or 11α-hydroxypregn-4-ene-3,20-dione is an endogenous steroid and metabolite of progesterone. It is a weak antiandrogen, and is devoid of androgenic, estrogenic, and progestogenic activity. Because of its inhibition of 11β-HSD and consequent potentiation of corticosteroids, 11α-OHP has recently been patented for the treatment of skin diseases, particularly psoriasis in combination with clobetasol propionate and minoxidil. 11α-OHP is used as a precursor in chemical syntheses of cortisone and hydrocortisone. (en) |
| rdfs:label | 11α-Hydroxyprogesterone (en) 11α-羟孕酮 (zh) |
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