3-Deazaneplanocin A (original) (raw)
3-Deazaneplanocin A (DZNep, C-c3Ado) is a drug which acts as both a S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has in vitro against a variety of different tumor cell lines. In studies on mice, the drug was also found to be effective for the treatment of Ebola virus disease, apparently interfering with the Ebola viruses ability to block interferon production, thus restoring the ability of immune system to rid the body of ebolavirus.
| Property | Value |
|---|---|
| dbo:abstract | 3-Deazaneplanocin A (DZNep, C-c3Ado) is a drug which acts as both a S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has in vitro against a variety of different tumor cell lines. In studies on mice, the drug was also found to be effective for the treatment of Ebola virus disease, apparently interfering with the Ebola viruses ability to block interferon production, thus restoring the ability of immune system to rid the body of ebolavirus. (en) La 3-déazaneplanocine A (DZNep) est un inhibiteur de l'adénosylhomocystéinase, une enzyme qui synthétise la S-adénosylhomocystéine. Des études ont montré qu'elle agit comme médicament anti-cancer des tumeurs colorectales et de l'ovaire. Des études menées sur des souris ont montré que la 3-déazaneplanocine A peut agir contre la maladie à virus Ebola, semble-t-il en interférant avec la capacité du virus Ebola de bloquer la production d'interféron pour échapper au système immunitaire. (fr) |
| dbo:iupacName | (1S,2R,5R)-5-(6-Amino-9H-purin-9-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/3-Deazaneplanocin_A.svg?width=300 |
| dbo:wikiPageID | 40313251 (xsd:integer) |
| dbo:wikiPageLength | 5629 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1051344110 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:EZH2 dbr:In_vitro dbc:Cyclopentenes dbc:Experimental_drugs dbc:Polyols dbr:S-Adenosyl-L-homocysteine dbc:Imidazopyridines dbc:Nucleosides dbr:Ebola_virus_disease dbr:Histone_methyltransferase dbr:Interferon dbr:Cell_line |
| dbp:imagefile | 3 (xsd:integer) |
| dbp:imagesize | 200 (xsd:integer) |
| dbp:pin | -5 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Fdacite dbt:Filoviridae dbt:Immunology-stub |
| dcterms:subject | dbc:Cyclopentenes dbc:Experimental_drugs dbc:Polyols dbc:Imidazopyridines dbc:Nucleosides |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound dbo:Drug |
| rdfs:comment | 3-Deazaneplanocin A (DZNep, C-c3Ado) is a drug which acts as both a S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has in vitro against a variety of different tumor cell lines. In studies on mice, the drug was also found to be effective for the treatment of Ebola virus disease, apparently interfering with the Ebola viruses ability to block interferon production, thus restoring the ability of immune system to rid the body of ebolavirus. (en) La 3-déazaneplanocine A (DZNep) est un inhibiteur de l'adénosylhomocystéinase, une enzyme qui synthétise la S-adénosylhomocystéine. Des études ont montré qu'elle agit comme médicament anti-cancer des tumeurs colorectales et de l'ovaire. Des études menées sur des souris ont montré que la 3-déazaneplanocine A peut agir contre la maladie à virus Ebola, semble-t-il en interférant avec la capacité du virus Ebola de bloquer la production d'interféron pour échapper au système immunitaire. (fr) |
| rdfs:label | 3-Deazaneplanocin A (en) 3-Déazaneplanocine A (fr) |
| owl:sameAs | freebase:3-Deazaneplanocin A yago-res:3-Deazaneplanocin A wikidata:3-Deazaneplanocin A dbpedia-fr:3-Deazaneplanocin A dbpedia-sh:3-Deazaneplanocin A dbpedia-sr:3-Deazaneplanocin A https://global.dbpedia.org/id/YEQc |
| prov:wasDerivedFrom | wikipedia-en:3-Deazaneplanocin_A?oldid=1051344110&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/3-Deazaneplanocin_A.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:3-Deazaneplanocin_A |
| is dbo:wikiPageRedirects of | dbr:C12H14N4O3 dbr:DZNep |
| is dbo:wikiPageWikiLink of | dbr:EZH2 dbr:C12H14N4O3 dbr:DZNep dbr:Imidazopyridine |
| is foaf:primaryTopic of | wikipedia-en:3-Deazaneplanocin_A |
