| dbo:abstract |
5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5'nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides. The enzyme has a wide substrate specificity for nucleotides and has been shown to hydrolyze 5'nucleotides rapidly, ribose-5-phosphate slowly, and other phosphate esters extremely slowly (if at all). The enzyme catalyses the following reaction: a 5′-nucleotide + H2O ⇌ a nucleoside + phosphate The 5′-nucleotidase-catalyzed reaction of an AMP nucleotide to adenosine nucleoside is shown below: (en) La 5'-nucleotidasa (EC 3.1.3.5), es una enzima que cataliza la siguiente reacción química: un 5'-ribonucleótido + H2O un ribonucleósido + fosfato Por lo tanto los dos sustratos de esta enzima son un 5'-ribonucleótido y agua, mientras que sus dos productos son un ribonucleósido y fosfato. (es) 5'-ヌクレオチダーゼ(5'-nucleotidase、EC 3.1.3.5)は、5'-リボヌクレオチド ホスホヒドロラーゼという系統名を持つ酵素である。以下の化学反応を触媒する。 5'-リボヌクレオチド + 水リボヌクレオシド + リン酸 従って、この酵素の2つの基質は5'-リボヌクレオチドと水、2つの生成物はリボヌクレオシドとリン酸である。 この酵素は、5'-ヌクレオチドに対して広い特異性を持つ。 (ja) |
| dbo:ecNumber |
3.1.3.5 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/5NT_PDB_Image.png?width=300 |
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5812160 (xsd:integer) |
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| dbo:wikiPageWikiLink |
dbr:Nucleotide dbr:Hepatobiliary dbr:Bone dbr:Nucleoside dbc:EC_3.1.3 dbr:Liver_function_test dbr:Cholestasis dbr:Hemolysis dbr:Autism_spectrum_disorder dbr:B_cells dbr:Wiskott–Aldrich_syndrome dbr:HIV dbr:Lead_poisoning dbr:Thymocyte dbr:Adenosine_monophosphate dbr:Alkaline_phosphatase dbr:Ischemia dbr:T_cells dbr:Hepatitis dbr:Phosphate dbr:Glycophosphatidylinositol dbr:Catalysis dbr:Immunodeficiency dbr:File:5'nucleotidase_membrane-bound_and_soluble_form_schematic.png dbr:File:5NT_Active_Site.png dbr:File:AMP_to_Adenosine_5'nucleotidase_catalyzed_reaction.png |
| dbp:caption |
Human ecto-5'-nucleotidase : crystal form I in complex with adenosine (en) |
| dbp:casNumber |
9027 (xsd:integer) |
| dbp:ecNumber |
3.100000 (xsd:double) |
| dbp:iubmbEcNumber |
3 (xsd:integer) |
| dbp:name |
5 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Enzymes dbt:Eqm dbt:Esterases dbt:Infobox_enzyme dbt:MeshName dbt:Portal_bar dbt:Reflist |
| dct:subject |
dbc:EC_3.1.3 |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment |
La 5'-nucleotidasa (EC 3.1.3.5), es una enzima que cataliza la siguiente reacción química: un 5'-ribonucleótido + H2O un ribonucleósido + fosfato Por lo tanto los dos sustratos de esta enzima son un 5'-ribonucleótido y agua, mientras que sus dos productos son un ribonucleósido y fosfato. (es) 5'-ヌクレオチダーゼ(5'-nucleotidase、EC 3.1.3.5)は、5'-リボヌクレオチド ホスホヒドロラーゼという系統名を持つ酵素である。以下の化学反応を触媒する。 5'-リボヌクレオチド + 水リボヌクレオシド + リン酸 従って、この酵素の2つの基質は5'-リボヌクレオチドと水、2つの生成物はリボヌクレオシドとリン酸である。 この酵素は、5'-ヌクレオチドに対して広い特異性を持つ。 (ja) 5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. Although originally found in snake venom, the activity of 5'nucleotidase has been described for bacteria and plant cells, and is widely distributed in vertebrate tissue. In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. Consequently, the enzyme plays a key role in the metabolism of nucleotides. (en) |
| rdfs:label |
5'-nucleotidase (en) 5'-Nucleotidasa (es) 5'-ヌクレオチダーゼ (ja) |
| owl:sameAs |
freebase:5'-nucleotidase wikidata:5'-nucleotidase dbpedia-es:5'-nucleotidase dbpedia-ja:5'-nucleotidase dbpedia-sh:5'-nucleotidase dbpedia-sr:5'-nucleotidase https://global.dbpedia.org/id/2LG9C |
| prov:wasDerivedFrom |
wikipedia-en:5'-nucleotidase?oldid=1105459066&ns=0 |
| foaf:depiction |
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wikipedia-en:5'-nucleotidase |
| foaf:name |
5′-nucleotidase (en) |
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dbr:List_of_EC_numbers_(EC_3) dbr:List_of_MeSH_codes_(D23) dbr:Nucleic_acid_metabolism dbr:Nucleotidase dbr:Cladribine dbr:Cholestasis dbr:Snake_venom dbr:Adenosine_monophosphate_deaminase_deficiency_type_1 dbr:Causes_of_autism dbr:Legionella_pneumophila dbr:List_of_MeSH_codes_(D08) dbr:Indian_cobra dbr:List_of_therapeutic_monoclonal_antibodies dbr:Oleclumab dbr:Periplasm dbr:Uridine_5'-nucleotidase dbr:UMPase dbr:IMP_5'-nucleotidase dbr:5'-AMP_nucleotidase dbr:5'-AMPase dbr:5'-adenylic_phosphatase dbr:5'-mononucleotidase dbr:5'-ribonucleotide_phosphohydrolase dbr:AMP_phosphatase dbr:AMP_phosphohydrolase dbr:AMPase dbr:Adenosine_5'-phosphatase dbr:Adenosine_monophosphatase dbr:Snake_venom_5'-nucleotidase dbr:EC_3.1.3.5 dbr:Thimidine_monophosphate_nucleotidase |
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