| dbo:abstract |
6′-Guanidinonaltrindole (6′-GNTI) is a κ–δ-opioid receptor selective ligand used in scientific research. With 6′-GNTI, evidence was provided for the first time that receptor oligomerization plays functional role in living organisms. 6′-GNTI is an extremely biased agonist of the κ-opioid receptor. It is a potent partial agonist of the G protein pathway but does not recruit the β-arrestin pathway. Due to its functional selectivity for the G protein pathway, 6′-GNTI functions as an antagonist of nonbiased KOR agonists on the β-arrestin pathway. It is thought that 6′-GTNI may be able to produce analgesia without dysphoria and with a lower incidence of tolerance. (en) |
| dbo:iupacName |
N-[(4bS,8R,8aS,14bR)-7-(Cyclopropylmethyl)-1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-b]pyrido[4,3-c]carbazol-12-yl]guanidine (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/6′-Guanidinonaltrindole.svg?width=300 |
| dbo:wikiPageID |
40935085 (xsd:integer) |
| dbo:wikiPageLength |
3364 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
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| dbo:wikiPageWikiLink |
dbr:Partial_agonist dbr:Δ-opioid_receptor dbc:Guanidines dbc:Semisynthetic_opioids dbr:Opioid_receptor dbc:Kappa-opioid_receptor_agonists dbr:Functional_selectivity dbr:Receptor_antagonist dbc:Biased_ligands dbc:Receptor_heteromer_ligands dbr:Drug_tolerance dbr:GPCR_oligomer dbr:G_protein dbr:5'-Guanidinonaltrindole dbr:Analgesia dbc:Indolomorphinans dbc:Kappa-opioid_receptor_antagonists dbr:Dysphoria dbr:Noribogaine dbr:ICI-199,441 dbr:RB-64 dbr:Κ-opioid_receptor dbr:Biased_agonist dbr:Β-arrestin |
| dbp:imagefile |
6 (xsd:integer) |
| dbp:imagesize |
200 (xsd:integer) |
| dbp:name |
6 (xsd:integer) |
| dbp:pin |
N-[-7--1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-b]pyrido[4,3-c]carbazol-12-yl]guanidine (en) |
| dbp:wikiPageUsesTemplate |
dbt:Analgesic-stub dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Opioidergics dbt:Reflist |
| dct:subject |
dbc:Guanidines dbc:Semisynthetic_opioids dbc:Kappa-opioid_receptor_agonists dbc:Biased_ligands dbc:Receptor_heteromer_ligands dbc:Indolomorphinans dbc:Kappa-opioid_receptor_antagonists |
| gold:hypernym |
dbr:Ligand |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatBiasedLigands yago:Ligand115110307 yago:Matter100020827 yago:PhysicalEntity100001930 dbo:ChemicalCompound yago:Substance100020090 yago:WikicatReceptorHeteromerLigands |
| rdfs:comment |
6′-Guanidinonaltrindole (6′-GNTI) is a κ–δ-opioid receptor selective ligand used in scientific research. With 6′-GNTI, evidence was provided for the first time that receptor oligomerization plays functional role in living organisms. (en) |
| rdfs:label |
6'-Guanidinonaltrindole (en) |
| owl:sameAs |
freebase:6'-Guanidinonaltrindole yago-res:6'-Guanidinonaltrindole wikidata:6'-Guanidinonaltrindole dbpedia-sr:6'-Guanidinonaltrindole https://global.dbpedia.org/id/ZRtx |
| prov:wasDerivedFrom |
wikipedia-en:6'-Guanidinonaltrindole?oldid=1088659551&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/6′-Guanidinonaltrindole.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:6'-Guanidinonaltrindole |
| foaf:name |
6′-Guanidinonaltrindole (en) |
| is dbo:wikiPageWikiLink of |
dbr:List_of_opioids dbr:C27H29N5O3 dbr:GNTI dbr:Guanidinonaltrindole dbr:5'-Guanidinonaltrindole dbr:Noribogaine dbr:Κ-opioid_receptor |
| is foaf:primaryTopic of |
wikipedia-en:6'-Guanidinonaltrindole |
