6-Methyl-MDA (original) (raw)
6-Methyl-3,4-methylenedioxyamphetamine (6-Methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class. It was first synthesized in the late 1990s by a team including David E. Nichols at Purdue University while investigating derivatives of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxy-N-methylamphetamine (MDMA).
| Property | Value |
|---|---|
| dbo:abstract | 6-Methyl-3,4-methylenedioxyamphetamine (6-Methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class. It was first synthesized in the late 1990s by a team including David E. Nichols at Purdue University while investigating derivatives of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxy-N-methylamphetamine (MDMA). 6-Methyl-MDA has IC50 values of 783 nM, 28,300 nM, and 4,602 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine in rat synaptosomes. In animal studies it substitutes for MBDB, MMAI, LSD, and 2,5-dimethoxy-4-iodoamphetamine (DOI), though not amphetamine, but only partially and at high doses. Thus, while several-fold less potent than its analogues 2-methyl-MDA and 5-methyl-MDA, and approximately half as potent as MDA, 6-methyl-MDA is still significantly active, and appropriate doses may be similar to or somewhat higher than those of MDMA. (en) La 6-metil-3,4-metilendiossiamestamina (noto anche come 6-Metil-MDA) è un farmaco entactogeno e psichedelico della classe delle anfetamine. È stato sintetizzato per la prima volta alla fine degli anni 90 da una squadra di chimici che includeva David E. Nichols alla Purdue University mentre si studiavano i derivati di MDA e MDMA. 6-Metil-MDA ha valori IC 50 di 783nM, 28,300nM e 4.602nM per inibire la ricaptazione di serotonina, dopamina e noradrenalina nei sinaptosomi di ratto. Negli studi sugli animali sostituisce MBDB , MMAI , LSD e DOI , sebbene non sia un'anfetamina, ma solo parzialmente e a dosi elevate. Così, sebbene è meno potente dei suoi analoghi 2-Metil-MDA e 5-Metil-MDA e circa la metà meno potente dell'MDA, il 6-metil-MDA è ancora significativamente attivo. (it) |
| dbo:casNumber | 246861-21-2 |
| dbo:chEMBL | 6376 |
| dbo:pubchem | 10511982 |
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| gold:hypernym | dbr:Entactogen |
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| rdfs:comment | 6-Methyl-3,4-methylenedioxyamphetamine (6-Methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class. It was first synthesized in the late 1990s by a team including David E. Nichols at Purdue University while investigating derivatives of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxy-N-methylamphetamine (MDMA). (en) La 6-metil-3,4-metilendiossiamestamina (noto anche come 6-Metil-MDA) è un farmaco entactogeno e psichedelico della classe delle anfetamine. È stato sintetizzato per la prima volta alla fine degli anni 90 da una squadra di chimici che includeva David E. Nichols alla Purdue University mentre si studiavano i derivati di MDA e MDMA. 6-Metil-MDA ha valori IC 50 di 783nM, 28,300nM e 4.602nM per inibire la ricaptazione di serotonina, dopamina e noradrenalina nei sinaptosomi di ratto. (it) |
| rdfs:label | 6-Methyl-MDA (en) 6-Metil-MDA (it) |
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