ACADM (original) (raw)
ACADM (acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. These fatty acids are found in foods such as milk and certain oils, and they are also stored in the body's fat tissue. Medium-chain fatty acids are also produced when larger fatty acids are degraded. The ACADM gene is located on the short (p) arm of chromosome 1 at position 31, from base pair 75,902,302 to base pair 75,941,203.
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| dbo:abstract | ACADM (acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. These fatty acids are found in foods such as milk and certain oils, and they are also stored in the body's fat tissue. Medium-chain fatty acids are also produced when larger fatty acids are degraded. The acyl-coenzyme A dehydrogenase for medium-chain fatty acids (ACADM) enzyme is essential for converting these particular fatty acids to energy, especially during periods without food (fasting). The ACADM enzyme functions in mitochondria, the energy-producing centers within cells. It is found in the mitochondria of several types of tissues, particularly the liver. The ACADM gene is located on the short (p) arm of chromosome 1 at position 31, from base pair 75,902,302 to base pair 75,941,203. (en) Die mittlere-Kette-spezifische Acyl-Coenzym A-Dehydrogenase ist ein Enzym, das vom Gen ACADM kodiert wird. Das Enzym katalysiert den initialen Schritt der mitochondrialen β-Oxidation. Es ist dabei spezifisch für Acyl-Ketten mit einer Länge von 4 bis 16 C-Atomen. Mutationen im ACADM-Gen führen zu Ausfällen im Enzym, was wiederum zu Dysfunktion der Leber, Hypoglykämie bei Nüchternheit und Enzephalopathie führt. Dies kann zum Tod noch im Kindesalter führen. Neben dieser existieren noch Acyl-Coenzym A-Dehydrogenasen, die für kurze Ketten, für lange oder für sehr lange Ketten spezifisch sind. (de) ACADM (англ. Acyl-CoA dehydrogenase, C-4 to C-12 straight chain) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 421 амінокислот, а молекулярна маса — 46 588. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до оксидоредуктаз. Задіяний у таких біологічних процесах як метаболізм жирних кислот, метаболізм ліпідів. Білок має сайт для зв'язування з ФАД, флавопротеїном. Локалізований у мітохондрії. (uk) O ACADM (acil-coenzima A desidrogenase, C-4 de cadeia de C-12 em linha reta) é um gene que fornece instruções para fazer uma enzima chamada acil-coenzima A desidrogenase que é importante para quebrar (degradar) um certo grupo de gorduras chamadas . Esses ácidos graxos são encontrados em alimentos como leite e certos óleos, e eles também são armazenadas no tecido adiposo do corpo. Ácidos graxos de cadeia média também são produzidos quando os maiores ácidos graxos são degradados. A enzima acil-coenzima A desidrogenase dos ácidos graxos de cadeia média (ACADM) é essencial para a conversão particular destes ácidos graxos em energia, especialmente durante os períodos sem alimentação (jejum). A enzima ACADM funciona nas mitocôndrias, os centros produtores de energia dentro das células. É encontrado nas mitocôndrias de vários tipos de tecidos, especialmente do fígado. O gene ACADM está localizado no braço (p) curto do cromossomo 1 na posição 31, a partir do par de bases 75.902.302 para o par de bases 75.941.203. (pt) |
| dbo:wikiPageExternalLink | http://www.gdb.org/gdb-bin/genera/genera/hgd/GenomicSegment%3F!action=query&displayName=acadm https://web.archive.org/web/20160304030529/http:/www.genecards.org/cgi-bin/carddisp%3FACADM https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi%3Fbook=gene&part=mcad |
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| dbo:wikiPageWikiLink | dbr:Mutation dbr:Oil dbr:Gene dbr:Glutamic_acid dbr:Mitochondria dbr:Liver dbr:Lysine dbr:Fatty_acid dbr:Base-pair_substitution dbr:Amino_acid dbr:Base_pair dbr:Milk dbr:Chromosome_1_(human) dbr:Medium-chain_acyl-coenzyme_A_dehydrogenase_deficiency dbr:Medium-chain_fatty_acid dbr:Acyl-coenzyme_A_dehydrogenase |
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| gold:hypernym | dbr:Gene |
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| rdfs:comment | ACADM (acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. These fatty acids are found in foods such as milk and certain oils, and they are also stored in the body's fat tissue. Medium-chain fatty acids are also produced when larger fatty acids are degraded. The ACADM gene is located on the short (p) arm of chromosome 1 at position 31, from base pair 75,902,302 to base pair 75,941,203. (en) Die mittlere-Kette-spezifische Acyl-Coenzym A-Dehydrogenase ist ein Enzym, das vom Gen ACADM kodiert wird. Das Enzym katalysiert den initialen Schritt der mitochondrialen β-Oxidation. Es ist dabei spezifisch für Acyl-Ketten mit einer Länge von 4 bis 16 C-Atomen. Mutationen im ACADM-Gen führen zu Ausfällen im Enzym, was wiederum zu Dysfunktion der Leber, Hypoglykämie bei Nüchternheit und Enzephalopathie führt. Dies kann zum Tod noch im Kindesalter führen. (de) O ACADM (acil-coenzima A desidrogenase, C-4 de cadeia de C-12 em linha reta) é um gene que fornece instruções para fazer uma enzima chamada acil-coenzima A desidrogenase que é importante para quebrar (degradar) um certo grupo de gorduras chamadas . Esses ácidos graxos são encontrados em alimentos como leite e certos óleos, e eles também são armazenadas no tecido adiposo do corpo. Ácidos graxos de cadeia média também são produzidos quando os maiores ácidos graxos são degradados. A enzima acil-coenzima A desidrogenase dos ácidos graxos de cadeia média (ACADM) é essencial para a conversão particular destes ácidos graxos em energia, especialmente durante os períodos sem alimentação (jejum). A enzima ACADM funciona nas mitocôndrias, os centros produtores de energia dentro das células. É encontr (pt) ACADM (англ. Acyl-CoA dehydrogenase, C-4 to C-12 straight chain) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 1-ї хромосоми. Довжина поліпептидного ланцюга білка становить 421 амінокислот, а молекулярна маса — 46 588. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | ACADM (de) ACADM (en) ACADM (pt) ACADM (uk) |
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| prov:wasDerivedFrom | wikipedia-en:ACADM?oldid=1097215967&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:ACADM |
| is dbo:wikiPageRedirects of | dbr:Medium-chain_acyl-coenzyme_A_dehydrogenase |
| is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_1 dbr:Estrogen-related_receptor_alpha dbr:Chromosome_1 dbr:List_of_OMIM_disorder_codes dbr:ACAD9 dbr:MCAD dbr:Medium-chain_acyl-coenzyme_A_dehydrogenase_deficiency dbr:Medium-chain_acyl-coenzyme_A_dehydrogenase |
| is foaf:primaryTopic of | wikipedia-en:ACADM |