AGG01 (original) (raw)
AGG01 a peptide antibiotic discovered in the breast milk of the Tammar wallaby, reportedly one hundred times more powerful than penicillin in vitro. This compound was found to be effective against MRSA, E. coli, Streptococci, Salmonella, Bacillus subtilis, Pseudomonas spp., Proteus vulgaris, and Staphylococcus aureus. The compound was in preclinical development in 2007.
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| dbo:abstract | AGG01 a peptide antibiotic discovered in the breast milk of the Tammar wallaby, reportedly one hundred times more powerful than penicillin in vitro. This compound was found to be effective against MRSA, E. coli, Streptococci, Salmonella, Bacillus subtilis, Pseudomonas spp., Proteus vulgaris, and Staphylococcus aureus. AGG01 is a cationic peptide, which is a polycationic protein that is rich in positive residues of the amino acids arginine and lysine, and which folds into an amphipathic structure (one which has both hydrophobic and hydrophilic areas). These features mean that it can interact with the anionic lipids in the bacterial membrane, such as phosphatidylglycerol. It inserts itself into the membrane, by competing with cross-linking proteins between each membrane layer, and then sets up trans-membrane protein channels which induce ion transport out of the cell. This causes huge leakage via osmosis through these 'pores' and the general consensus is that the loss of these essential molecules is the mechanism by which bacteria are killed. The bacterial membrane has a different structure from the mammalian plasma membrane, so the protein can only kill pathogenic cells and not human ones. The compound was in preclinical development in 2007. (en) |
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| dbo:wikiPageWikiLink | dbr:Pseudomonas dbr:Methicillin-resistant_Staphylococcus_aureus dbr:Hydrophilic dbr:Penicillin dbr:Peptide dbr:In_vitro dbr:Preclinical_development dbr:Proteus_vulgaris dbr:Anionic dbr:Lipids dbr:Amphipathic dbr:Lysine dbr:Staphylococcus_aureus dbr:Amino_acids dbr:E._coli dbr:Protein dbr:Bacillus_subtilis dbr:Tammar_wallaby dbr:Arginine dbc:Antimicrobial_peptides dbr:Salmonella dbr:Hydrophobic dbr:Cationic dbr:Streptococci dbr:Peptide_antibiotic |
| dbp:wikiPageUsesTemplate | dbt:Medref dbt:Antibiotic-stub dbt:Reflist |
| dcterms:subject | dbc:Antimicrobial_peptides |
| rdf:type | yago:WikicatAntibiotics yago:Agent114778436 yago:Antibacterial102716205 yago:Antibiotic102716866 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:Substance100020090 |
| rdfs:comment | AGG01 a peptide antibiotic discovered in the breast milk of the Tammar wallaby, reportedly one hundred times more powerful than penicillin in vitro. This compound was found to be effective against MRSA, E. coli, Streptococci, Salmonella, Bacillus subtilis, Pseudomonas spp., Proteus vulgaris, and Staphylococcus aureus. The compound was in preclinical development in 2007. (en) |
| rdfs:label | AGG01 (en) |
| owl:sameAs | freebase:AGG01 yago-res:AGG01 wikidata:AGG01 https://global.dbpedia.org/id/4KPN7 |
| prov:wasDerivedFrom | wikipedia-en:AGG01?oldid=1117786090&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:AGG01 |
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| is foaf:primaryTopic of | wikipedia-en:AGG01 |