| dbo:abstract |
AS-19 is a substance which acts as a potent agonist at the 5-HT7 receptor, with an IC50 of 0.83nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long-term memory acquisition, but inhibits short-term memory formation. (en) AS-19 (fármaco) es una sustancia que actúa como un potente agonista del , con una IC 50 de 0,83 nM. Revierte la amnesia inducida por fármacos como la escopolamina y la dizocilpina y mejora la adquisición de la memoria a largo plazo, pero inhibe la formación de la memoria a corto plazo. (es) AS-19は、の強いアゴニストとして作用する物質である。IC50は、0.83 nMである。スコポラミンやMK-801等の薬剤の作用による健忘を逆転させ、長期記憶の獲得を改善するが、短期記憶の形成は阻害する。 (ja) |
| dbo:casNumber |
1000578-26-6 |
| dbo:chEMBL |
2164327 |
| dbo:fdaUniiCode |
LA5AQ5R6QS |
| dbo:pubchem |
23642275 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/AS-19.svg?width=300 |
| dbo:wikiPageID |
19837638 (xsd:integer) |
| dbo:wikiPageLength |
3084 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1075459455 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:E-55888 dbc:Dimethylamino_compounds dbc:5-HT7_agonists dbr:Agonist dbr:Amnesia dbr:5-HT7_receptor dbc:Pyrazoles dbc:Aminotetralins dbr:LP-12 dbr:LP-211 dbr:LP-44 dbr:Dizocilpine dbr:Hyoscine_hydrobromide |
| dbp:c |
18 (xsd:integer) |
| dbp:casNumber |
1000578 (xsd:integer) |
| dbp:chembl |
2164327 (xsd:integer) |
| dbp:chemspiderid |
24605931 (xsd:integer) |
| dbp:drugName |
AS-19 (en) |
| dbp:h |
25 (xsd:integer) |
| dbp:iupacName |
-N,N-dimethyl-5--1,2,3,4-tetrahydronaphthalen-2-amine (en) |
| dbp:n |
3 (xsd:integer) |
| dbp:pubchem |
23642275 (xsd:integer) |
| dbp:smiles |
CC1=CC2=C3CC[C@@H]NC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
BTTOYOKCLDAHHO-HNNXBMFYSA-N (en) |
| dbp:unii |
LA5AQ5R6QS (en) |
| dbp:verifiedrevid |
407703632 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:wikiPageUsesTemplate |
dbt:Amine-stub dbt:Drugbox dbt:Nervous-system-drug-stub dbt:Reflist dbt:Serotonergics dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite |
| dct:subject |
dbc:Dimethylamino_compounds dbc:5-HT7_agonists dbc:Pyrazoles dbc:Aminotetralins |
| gold:hypernym |
dbr:Substance |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAmines yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Amine114739004 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MethaneSeries114951377 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Statement106722453 yago:Substance100019613 umbel-rc:DrugProduct |
| rdfs:comment |
AS-19 is a substance which acts as a potent agonist at the 5-HT7 receptor, with an IC50 of 0.83nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long-term memory acquisition, but inhibits short-term memory formation. (en) AS-19 (fármaco) es una sustancia que actúa como un potente agonista del , con una IC 50 de 0,83 nM. Revierte la amnesia inducida por fármacos como la escopolamina y la dizocilpina y mejora la adquisición de la memoria a largo plazo, pero inhibe la formación de la memoria a corto plazo. (es) AS-19は、の強いアゴニストとして作用する物質である。IC50は、0.83 nMである。スコポラミンやMK-801等の薬剤の作用による健忘を逆転させ、長期記憶の獲得を改善するが、短期記憶の形成は阻害する。 (ja) |
| rdfs:label |
AS-19 (drug) (en) AS-19 (fármaco) (es) AS-19 (薬剤) (ja) |
| owl:sameAs |
freebase:AS-19 (drug) yago-res:AS-19 (drug) wikidata:AS-19 (drug) dbpedia-es:AS-19 (drug) dbpedia-fa:AS-19 (drug) dbpedia-ja:AS-19 (drug) dbpedia-sh:AS-19 (drug) dbpedia-sr:AS-19 (drug) https://global.dbpedia.org/id/51cke |
| prov:wasDerivedFrom |
wikipedia-en:AS-19_(drug)?oldid=1075459455&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/AS-19.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:AS-19_(drug) |
| foaf:name |
AS-19 (en) |
| is dbo:wikiPageRedirects of |
dbr:C18H25N3 |
| is dbo:wikiPageWikiLink of |
dbr:E-55888 dbr:2-Aminotetralin dbr:C18H25N3 dbr:5-HT7_receptor dbr:5-HT_receptor dbr:AS-19 dbr:LP-12 dbr:LP-211 dbr:LP-44 dbr:Serotonin_receptor_agonist |
| is foaf:primaryTopic of |
wikipedia-en:AS-19_(drug) |
