Allopregnanediol (original) (raw)
Allopregnanediol, or 5α-pregnane-3α,20α-diol, is an endogenous metabolite of progesterone and allopregnanolone and an isomer of pregnanediol (5β-pregnan-3α,20α-diol). It has been found to act like a partial agonist of an allosteric site of the GABA receptor and hence might play a biological role as a neurosteroid. It has also been found to act as an agonist of the human pregnane X receptor, albeit with an EC50 that is more than an order of magnitude lower than that of other endogenous pregnanes like pregnenolone, pregnanediol, allopregnanedione, and allopregnanolone.
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| dbo:abstract | Allopregnanediol, or 5α-pregnane-3α,20α-diol, is an endogenous metabolite of progesterone and allopregnanolone and an isomer of pregnanediol (5β-pregnan-3α,20α-diol). It has been found to act like a partial agonist of an allosteric site of the GABA receptor and hence might play a biological role as a neurosteroid. It has also been found to act as an agonist of the human pregnane X receptor, albeit with an EC50 that is more than an order of magnitude lower than that of other endogenous pregnanes like pregnenolone, pregnanediol, allopregnanedione, and allopregnanolone. (en) 别孕烷二醇（英語：Allopregnanediol，又称5α-孕烷-3α,20α-二醇，5α-pregnane-3α,20α-diol）是一种内源的孕酮和别孕烷醇酮代谢产物，也是孕烷二醇（5β-孕烷-3α,20α-二醇）立体同分异构体。别孕烷二醇能作为别构调节GABA受体的部分激动剂，因此可能起到的生物学作用，也能作为人的激动剂，尽管比其他内源性的孕烷衍生物（如孕烯醇酮、孕烷二醇、、别孕烷醇酮）低一个数量级以上。 (zh) |
| dbo:iupacName | (1S,3aS,3bR,5aS,7R,9aS,9bS,11aS)-1-[(1S)-1-Hydroxyethyl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-ol (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Allopregnanediol.svg?width=300 |
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| dbo:wikiPageLength | 3193 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1019559056 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Pregnane dbr:Pregnane_X_receptor dbr:Pregnanediol dbr:Pregnenolone dbr:Progesterone dbr:Metabolite dbr:Partial_agonist dbr:Human dbr:EC50 dbc:Diols dbc:GABAA_receptor_positive_allosteric_modulators dbc:Human_metabolites dbc:Neurosteroids dbc:Pregnanes dbc:Pregnane_X_receptor_agonists dbr:GABAA_receptor dbr:Agonist dbr:Allopregnanolone dbr:Allosteric_site dbr:Isomer dbr:Endogenous dbr:Neurosteroid dbr:Allopregnanedione |
| dbp:imagefile | Allopregnanediol.svg (en) |
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| dct:subject | dbc:Diols dbc:GABAA_receptor_positive_allosteric_modulators dbc:Human_metabolites dbc:Neurosteroids dbc:Pregnanes dbc:Pregnane_X_receptor_agonists |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Allopregnanediol, or 5α-pregnane-3α,20α-diol, is an endogenous metabolite of progesterone and allopregnanolone and an isomer of pregnanediol (5β-pregnan-3α,20α-diol). It has been found to act like a partial agonist of an allosteric site of the GABA receptor and hence might play a biological role as a neurosteroid. It has also been found to act as an agonist of the human pregnane X receptor, albeit with an EC50 that is more than an order of magnitude lower than that of other endogenous pregnanes like pregnenolone, pregnanediol, allopregnanedione, and allopregnanolone. (en) 别孕烷二醇（英語：Allopregnanediol，又称5α-孕烷-3α,20α-二醇，5α-pregnane-3α,20α-diol）是一种内源的孕酮和别孕烷醇酮代谢产物，也是孕烷二醇（5β-孕烷-3α,20α-二醇）立体同分异构体。别孕烷二醇能作为别构调节GABA受体的部分激动剂，因此可能起到的生物学作用，也能作为人的激动剂，尽管比其他内源性的孕烷衍生物（如孕烯醇酮、孕烷二醇、、别孕烷醇酮）低一个数量级以上。 (zh) |
| rdfs:label | Allopregnanediol (en) 别孕烷二醇 (zh) |
| rdfs:seeAlso | dbr:List_of_neurosteroids |
| owl:sameAs | wikidata:Allopregnanediol dbpedia-zh:Allopregnanediol https://global.dbpedia.org/id/2Y6Co |
| prov:wasDerivedFrom | wikipedia-en:Allopregnanediol?oldid=1019559056&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Allopregnanediol.svg |
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| is dbo:wikiPageWikiLink of | dbr:Quingestrone dbr:Pharmacokinetics_of_progesterone dbr:List_of_neurosteroids dbr:Pregnanediol_(disambiguation) dbr:5α-Dihydroprogesterone dbr:Allopregnane dbr:C21H36O2 dbr:5α-Pregnan-3α,20α-diol dbr:5α-Pregnane-3α,20α-diol dbr:5α-Pregnanediol dbr:5α-pregnan-3α,20α-diol dbr:5α-pregnane-3α,20α-diol dbr:5α-pregnanediol |
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