Alveolar rhabdomyosarcoma (original) (raw)
Alveolar rhabdomyosarcoma (ARMS) is a subtype of the rhabdomyosarcoma soft tissue cancer family whose lineage is from mesenchymal cells and are related to skeletal muscle cells. ARMS tumors resemble the alveolar tissue in the lungs. Tumor location varies from patient to patient, but is commonly found in the head and neck region, male and female urogenital tracts, the torso, and extremities. Two fusion proteins can be associated with ARMS, but are not necessary, PAX3-FKHR (now known as FOXO1). and PAX7-FKHR. In children and adolescents ARMS accounts for about 1 percent of all malignancies, has an incidence rate of 1 per million, and most cases occur sporadically with no genetic predisposition. PAX3-FOXO1 is now known to drive cancer-promoting gene expression programs through creation of dis
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|---|---|
| dbo:abstract | Alveolar rhabdomyosarcoma (ARMS) is a subtype of the rhabdomyosarcoma soft tissue cancer family whose lineage is from mesenchymal cells and are related to skeletal muscle cells. ARMS tumors resemble the alveolar tissue in the lungs. Tumor location varies from patient to patient, but is commonly found in the head and neck region, male and female urogenital tracts, the torso, and extremities. Two fusion proteins can be associated with ARMS, but are not necessary, PAX3-FKHR (now known as FOXO1). and PAX7-FKHR. In children and adolescents ARMS accounts for about 1 percent of all malignancies, has an incidence rate of 1 per million, and most cases occur sporadically with no genetic predisposition. PAX3-FOXO1 is now known to drive cancer-promoting gene expression programs through creation of distant genetic elements called super enhancers. (en) |
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| dbo:wikiPageWikiLink | dbr:Cancer dbr:Pulmonary_alveolus dbr:Mesoderm dbr:Pax_genes dbr:Rhabdomyosarcoma dbr:DNA-binding_domain dbr:CDH3_(gene) dbr:Genetic_recombination dbr:Surgery dbr:Transcription_(biology) dbr:Super-enhancer dbc:Sarcoma dbr:FOXO1 dbr:Chromosomal_translocation dbr:Protein_domain dbr:AP2B1 dbr:Chemotherapy dbr:Soft-tissue_sarcoma dbr:Nasopharynx dbr:Oncology dbr:Radiation_therapy dbr:Lung dbr:FOX_proteins dbr:Immunostaining dbr:MyoD dbr:Myogenin dbr:Oncogene dbr:PAX3 dbr:PAX7 dbr:Septum |
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| dbp:name | Alveolar rhabdomyosarcoma (en) |
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| dcterms:subject | dbc:Sarcoma |
| gold:hypernym | dbr:Rhabdomyosarcoma |
| rdf:type | owl:Thing wikidata:Q12136 dbo:Disease umbel-rc:AilmentCondition |
| rdfs:comment | Alveolar rhabdomyosarcoma (ARMS) is a subtype of the rhabdomyosarcoma soft tissue cancer family whose lineage is from mesenchymal cells and are related to skeletal muscle cells. ARMS tumors resemble the alveolar tissue in the lungs. Tumor location varies from patient to patient, but is commonly found in the head and neck region, male and female urogenital tracts, the torso, and extremities. Two fusion proteins can be associated with ARMS, but are not necessary, PAX3-FKHR (now known as FOXO1). and PAX7-FKHR. In children and adolescents ARMS accounts for about 1 percent of all malignancies, has an incidence rate of 1 per million, and most cases occur sporadically with no genetic predisposition. PAX3-FOXO1 is now known to drive cancer-promoting gene expression programs through creation of dis (en) |
| rdfs:label | Alveolar rhabdomyosarcoma (en) |
| owl:sameAs | freebase:Alveolar rhabdomyosarcoma wikidata:Alveolar rhabdomyosarcoma dbpedia-fa:Alveolar rhabdomyosarcoma https://global.dbpedia.org/id/4PwrC |
| prov:wasDerivedFrom | wikipedia-en:Alveolar_rhabdomyosarcoma?oldid=1090686863&ns=0 |
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| foaf:name | Alveolar rhabdomyosarcoma (en) |
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| is foaf:primaryTopic of | wikipedia-en:Alveolar_rhabdomyosarcoma |