| dbo:abstract |
The enzyme amorpha-4,11-diene synthase (EC 4.2.3.24) (ADS) catalyzes the chemical reaction (2E,6E)-farnesyl diphosphate ⇌ amorpha-4,11-diene + diphosphate This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming). This enzyme is also called amorphadiene synthase. This enzyme is mainly found in Artemisia annua, a temperate Asian native flowering plant, and ADS catalyzes the first committed step in the antimalarial drug artemisinin synthesis. (en) |
| dbo:ecNumber |
4.2.3.24 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/ADS_regulation.jpg?width=300 |
| dbo:wikiPageID |
14323686 (xsd:integer) |
| dbo:wikiPageLength |
12127 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1102322860 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:List_of_enzymes dbr:Metabolic_engineering dbr:Deprotonation dbr:MRNA dbc:EC_4.2.3 dbc:Enzymes_of_unknown_structure dbr:Chemical_reaction dbr:Enzyme dbr:Angiosperms dbr:Amorpha-4,11-diene dbr:Amyris_(company) dbr:Isoelectric_point dbr:Isomerization dbr:CDNA dbr:Artemisinin dbr:Artemisia_annua dbr:Catalysis dbr:Lyase dbr:Mevalonate dbr:Farnesyl_diphosphate dbr:Aspartate dbr:Olefins dbr:Squalene_synthase dbr:File:ADS_regulation.JPG dbr:File:Amorpha-4,11-diene_to_artemisinin.jpg dbr:File:Mechanism_of_Amorpha-4,11-diene_synthase.jpg |
| dbp:date |
September 2016 (en) |
| dbp:ecNumber |
4.200000 (xsd:double) |
| dbp:iubmbEcNumber |
4 (xsd:integer) |
| dbp:name |
Amorpha-4,11-diene synthase (en) |
| dbp:reason |
Bioinformation is on Beall's list of questionable journals; it may provide only token peer-review (en) |
| dbp:wikiPageUsesTemplate |
dbt:Carbon-oxygen_lyases dbt:Enzyme dbt:Enzymes dbt:Portal_bar dbt:Reflist dbt:Unreliable_source? |
| dcterms:subject |
dbc:EC_4.2.3 dbc:Enzymes_of_unknown_structure |
| gold:hypernym |
dbr:Enzyme |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatEnzymesOfUnknownStructure |
| rdfs:comment |
The enzyme amorpha-4,11-diene synthase (EC 4.2.3.24) (ADS) catalyzes the chemical reaction (2E,6E)-farnesyl diphosphate ⇌ amorpha-4,11-diene + diphosphate This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming). This enzyme is also called amorphadiene synthase. (en) |
| rdfs:label |
Amorpha-4,11-diene synthase (en) |
| owl:sameAs |
freebase:Amorpha-4,11-diene synthase yago-res:Amorpha-4,11-diene synthase wikidata:Amorpha-4,11-diene synthase dbpedia-sh:Amorpha-4,11-diene synthase dbpedia-sr:Amorpha-4,11-diene synthase https://global.dbpedia.org/id/4Pbqr |
| prov:wasDerivedFrom |
wikipedia-en:Amorpha-4,11-diene_synthase?oldid=1102322860&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/ADS_regulation.jpg wiki-commons:Special:FilePath/Amorpha-4,11-diene_to_artemisinin.jpg wiki-commons:Special:FilePath/Mechanism_of_Amorpha-4,11-diene_synthase.jpg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Amorpha-4,11-diene_synthase |
| foaf:name |
Amorpha-4,11-diene synthase (en) |
| is dbo:wikiPageRedirects of |
dbr:EC_4.2.3.24 dbr:(2E,6E)-farnesyl-diphosphate_diphosphate-lyase_(amorpha-4,11-diene-forming) |
| is dbo:wikiPageWikiLink of |
dbr:Amorpha-4,11-diene dbr:List_of_EC_numbers_(EC_4) dbr:Artemisinin dbr:EC_4.2.3.24 dbr:(2E,6E)-farnesyl-diphosphate_diphosphate-lyase_(amorpha-4,11-diene-forming) |
| is foaf:primaryTopic of |
wikipedia-en:Amorpha-4,11-diene_synthase |
