Anol (original) (raw)
H ανόλη (αγγλικά anol) είναι αρωματική οργανική χημική ένωση, που περιέχει άνθρακα, υδρογόνο και οξυγόνο, με μοριακό τύπο C9H10O, αν και αποδίδεται πιο αναλυτικά από τον ημισυντακτικό του τύπο (C6H4)(4-CH=CHCH3)OH. Πιο συγκεκριμένα, είναι μια φαινόλη.
| Property | Value |
|---|---|
| dbo:abstract | H ανόλη (αγγλικά anol) είναι αρωματική οργανική χημική ένωση, που περιέχει άνθρακα, υδρογόνο και οξυγόνο, με μοριακό τύπο C9H10O, αν και αποδίδεται πιο αναλυτικά από τον ημισυντακτικό του τύπο (C6H4)(4-CH=CHCH3)OH. Πιο συγκεκριμένα, είναι μια φαινόλη. (el) Anol, also known as para-hydroxypropenylbenzene, is a simple phenol that was derived via demethylation from anethole, an estrogenic constituent of anise and fennel, by Sir Charles Dodds in 1937. It was reported to possess extremely potent estrogenic activity on par with that of steroidal estrogens like estrone, with a dose of 1 μg inducing estrus in rats. However, subsequent studies with different preparations of anol failed to confirm these findings, and it was found that dimerization of anol into dianol and hexestrol can rapidly occur and that the latter impurity was responsible for the highly potent estrogenic effects. Dodds later synthesized the structurally related and extremely potent estrogen diethylstilbestrol in 1938. (en) L’Anolo, conosciuto anche come para-idrossipropenilbenzene, è un fenolo che fu ottenuto dalla demetilazione dell'anetolo, un costituente estrogeno dell'anice e del finocchio, da Sir Charles Dodds nel 1937. Fu osservata una sua attività estrogena estremamente potente, comparabile a quella di estrogeni steroidei come l'estrone: una dose di 1 µg era in grado di indurre l'estro nei ratti. Tuttavia, studi successivi con diverse preparazioni dell'anolo non riuscirono a confermare queste osservazioni; si osservò che può verificarsi in poco tempo la dimerizzazione dell'anolo in dianolo ed esestrolo, e che queste impurità sono di fatto responsabili dei potenti effetti estrogeni osservati. Dodds sintetizzò in seguito il potente estrogeno dietilstilbestrolo, strutturalmente correlato all'Anolo, nel 1938. (it) |
| dbo:casNumber | 85960-81-2 |
| dbo:fdaUniiCode | VQ6PDW0YG3 |
| dbo:pubchem | 415627 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Anol.svg?width=300 |
| dbo:wikiPageID | 45496011 (xsd:integer) |
| dbo:wikiPageLength | 4251 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1084691381 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Anise dbc:Estrogens dbc:Phenols dbr:Estrogen dbr:Anethole dbr:Steroid dbr:Demethylation dbr:Fennel dbr:Estrone dbr:Estrus dbr:Dianol dbr:Dimer_(chemistry) dbr:Hexestrol dbr:Dianethole dbr:Diethylstilbestrol dbr:Phenol dbr:Sir_Charles_Dodds |
| dbp:atcPrefix | None (en) |
| dbp:c | 9 (xsd:integer) |
| dbp:casNumber | 85960 (xsd:integer) |
| dbp:chemspiderid | 367976 (xsd:integer) |
| dbp:h | 10 (xsd:integer) |
| dbp:iupacName | 4 (xsd:integer) |
| dbp:o | 1 (xsd:integer) |
| dbp:pubchem | 415627 (xsd:integer) |
| dbp:smiles | CC=CC1=CC=CO (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | UMFCIIBZHQXRCJ-UHFFFAOYSA-N (en) |
| dbp:unii | VQ6PDW0YG3 (en) |
| dbp:width | 250 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Estrogen_receptor_modulators dbt:Genito-urinary-drug-stub dbt:Reflist dbt:Short_description dbt:Fdacite |
| dct:subject | dbc:Estrogens dbc:Phenols |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | H ανόλη (αγγλικά anol) είναι αρωματική οργανική χημική ένωση, που περιέχει άνθρακα, υδρογόνο και οξυγόνο, με μοριακό τύπο C9H10O, αν και αποδίδεται πιο αναλυτικά από τον ημισυντακτικό του τύπο (C6H4)(4-CH=CHCH3)OH. Πιο συγκεκριμένα, είναι μια φαινόλη. (el) Anol, also known as para-hydroxypropenylbenzene, is a simple phenol that was derived via demethylation from anethole, an estrogenic constituent of anise and fennel, by Sir Charles Dodds in 1937. It was reported to possess extremely potent estrogenic activity on par with that of steroidal estrogens like estrone, with a dose of 1 μg inducing estrus in rats. However, subsequent studies with different preparations of anol failed to confirm these findings, and it was found that dimerization of anol into dianol and hexestrol can rapidly occur and that the latter impurity was responsible for the highly potent estrogenic effects. Dodds later synthesized the structurally related and extremely potent estrogen diethylstilbestrol in 1938. (en) L’Anolo, conosciuto anche come para-idrossipropenilbenzene, è un fenolo che fu ottenuto dalla demetilazione dell'anetolo, un costituente estrogeno dell'anice e del finocchio, da Sir Charles Dodds nel 1937. Fu osservata una sua attività estrogena estremamente potente, comparabile a quella di estrogeni steroidei come l'estrone: una dose di 1 µg era in grado di indurre l'estro nei ratti. Dodds sintetizzò in seguito il potente estrogeno dietilstilbestrolo, strutturalmente correlato all'Anolo, nel 1938. (it) |
| rdfs:label | Ανόλη (el) Anol (en) Anolo (it) |
| owl:sameAs | yago-res:Anol wikidata:Anol dbpedia-el:Anol dbpedia-it:Anol https://global.dbpedia.org/id/2XCUL |
| prov:wasDerivedFrom | wikipedia-en:Anol?oldid=1084691381&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Anol.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Anol |
| is dbo:wikiPageRedirects of | dbr:Para-hydroxypropenylbenzene |
| is dbo:wikiPageWikiLink of | dbr:C9H10O dbr:Anethole dbr:Stilbestrol dbr:Demethylation dbr:Dianol dbr:Chavicol dbr:Dianethole dbr:Diethylstilbestrol dbr:Photoanethole dbr:Para-hydroxypropenylbenzene |
| is foaf:primaryTopic of | wikipedia-en:Anol |
