Anti-Scl-70 antibodies (original) (raw)
Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome. Anti Scl-70 antibodies are associated with more severe scleroderma disease.
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| dbo:abstract | Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome. Anti Scl-70 antibodies are associated with more severe scleroderma disease. The etymology of scl-70 consists of an abbreviation of scleroderma and a 70 kD extractable immunoreactive fragment that can be obtained from the otherwise larger (100–105 kD) target topoisomerase antigen (called the SCL-70 Antigen) of the antibodies. (en) Gli anticorpi anti-Scl-70, anche chiamati anti-topoisomerasi I dal momento che legano la del relativo enzima, sono autoanticorpi diretti verso antigeni nucleari estraibili associati a numerose malattie autoimmuni, ma riscontrabili principalmente nella forma diffusa sclerodermia, con una sensibilità del 28–70%, ma presenti anche nel 10–18% dei casi di sindrome CREST. La presenza di anticorpi anti-Scl-70 è associata ad una forma di sclerodermia severa. La denominazione deriva da sclerodermia e 70 kD, ovvero la dimensione del frammento immunoreattivo estraibile dal più grande antigene, di dimensioni pari a 100–105 kD, che si è rivelato essere la stessa topoisomerasi I. (it) |
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| rdfs:comment | Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome. Anti Scl-70 antibodies are associated with more severe scleroderma disease. (en) Gli anticorpi anti-Scl-70, anche chiamati anti-topoisomerasi I dal momento che legano la del relativo enzima, sono autoanticorpi diretti verso antigeni nucleari estraibili associati a numerose malattie autoimmuni, ma riscontrabili principalmente nella forma diffusa sclerodermia, con una sensibilità del 28–70%, ma presenti anche nel 10–18% dei casi di sindrome CREST. La presenza di anticorpi anti-Scl-70 è associata ad una forma di sclerodermia severa. (it) |
| rdfs:label | Anti-Scl-70 antibodies (en) Anticorpi anti-Scl-70 (it) |
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