Asmic (original) (raw)

Anisyl sulfanyl methyl isocyanide (Asmic) is an organic molecule that contains an isocyanide group and an ortho-methoxy-phenyl sulfide group. Asmic can be used to synthesize tri-substituted isocyanides. Asmic is a colorless to off-white solid with a melting point of 27 °C that can be prepared by dehydration of the corresponding formamide by POCl3. The ortho-methoxy-phenyl sulfide group is thought to facilitate deprotonation by chelating to metalated bases allowing for the base to achieve optimal trajectory during the deprotonation.