| dbo:abstract |
Barbituráza je amidohydroláza obsahující zinek. Barbituráza funguje jako katalyzátor ve druhém kroku oxidační degradace pyrimidinů, podporuje hydrolýzu (s otevřením kruhu) kyseliny barbiturové na . Byť patří do skupiny přirozeně existujících amidohydroláz, vykazuje větší homologii s amidohydrolázou kyselinou kyanurovou. Proto bylo navrženo, aby byla barbituráza společně s kyselinou kyanurovou umístěna do nové skupiny.KEGG (cs) Barbiturase (EC 3.5.2.1) is a zinc-containing amidohydrolase. Its systemic name is barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming). Barbiturase acts as a catalyst in the second step of oxidative pyrimidine degradation, promoting the ring-opening hydrolysis of barbituric acid to ureidomalonic acid. Although grouped into the naturally existing amidohydrolases, it demonstrates more homology with cyanuric acid amidohydrolase. Therefore, it has been proposed that barbiturase, along with cyanuric acid, should be grouped into a new family.KEGG (en) |
| dbo:ecNumber |
3.5.2.1 |
| dbo:wikiPageExternalLink |
https://www.genome.jp/dbget-bin/www_bget%3Fenzyme+3.5.2.1 |
| dbo:wikiPageID |
10977574 (xsd:integer) |
| dbo:wikiPageLength |
3763 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1002500430 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Amidohydrolase dbr:Urea dbr:Pyrimidine_metabolism dbr:Enzyme dbr:Zinc dbr:Barbituric_acid dbr:Amino_acid dbr:Cyanuric_acid dbr:Carboxylic_acid dbc:EC_3.5.2 dbr:Histidine dbr:Hydrolysis dbr:Chelation dbr:Catalysis dbr:Malonate dbr:Molecular_weight |
| dbp:casNumber |
9025 (xsd:integer) |
| dbp:ecNumber |
3.500000 (xsd:double) |
| dbp:iubmbEcNumber |
3 (xsd:integer) |
| dbp:name |
Barbiturase (en) |
| dbp:wikiPageUsesTemplate |
dbt:Carbon-nitrogen_non-peptide_hydrolases dbt:EC_number dbt:Enzymes dbt:Infobox_enzyme dbt:Portal_bar dbt:Reflist dbt:MeSH_name |
| dcterms:subject |
dbc:EC_3.5.2 |
| gold:hypernym |
dbr:Zinc |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8047 yago:Abstraction100002137 yago:Activator114723079 yago:Catalyst114723628 yago:Chemical114806838 yago:Compound114818238 yago:Enzyme114732946 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:Enzyme yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment |
Barbituráza je amidohydroláza obsahující zinek. Barbituráza funguje jako katalyzátor ve druhém kroku oxidační degradace pyrimidinů, podporuje hydrolýzu (s otevřením kruhu) kyseliny barbiturové na . Byť patří do skupiny přirozeně existujících amidohydroláz, vykazuje větší homologii s amidohydrolázou kyselinou kyanurovou. Proto bylo navrženo, aby byla barbituráza společně s kyselinou kyanurovou umístěna do nové skupiny.KEGG (cs) Barbiturase (EC 3.5.2.1) is a zinc-containing amidohydrolase. Its systemic name is barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming). Barbiturase acts as a catalyst in the second step of oxidative pyrimidine degradation, promoting the ring-opening hydrolysis of barbituric acid to ureidomalonic acid. Although grouped into the naturally existing amidohydrolases, it demonstrates more homology with cyanuric acid amidohydrolase. Therefore, it has been proposed that barbiturase, along with cyanuric acid, should be grouped into a new family.KEGG (en) |
| rdfs:label |
Barbiturase (en) Barbituráza (cs) |
| owl:sameAs |
freebase:Barbiturase wikidata:Barbiturase dbpedia-cs:Barbiturase dbpedia-sh:Barbiturase dbpedia-sr:Barbiturase https://global.dbpedia.org/id/4Vt2i |
| prov:wasDerivedFrom |
wikipedia-en:Barbiturase?oldid=1002500430&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:Barbiturase |
| foaf:name |
Barbiturase (en) |
| is dbo:wikiPageRedirects of |
dbr:Barbiturate_amidohydrolase_(3-oxo-3-ureidopropanoate-forming) dbr:EC_3.5.2.1 |
| is dbo:wikiPageWikiLink of |
dbr:List_of_EC_numbers_(EC_3) dbr:Barbituric_acid dbr:Barbiturate_amidohydrolase_(3-oxo-3-ureidopropanoate-forming) dbr:EC_3.5.2.1 |
| is foaf:primaryTopic of |
wikipedia-en:Barbiturase |