Bisantrene (original) (raw)
Bisantrene, trademarked as Zantrene, is an with anthracycline-like antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike anthracyclines like doxorubicin, exhibits little cardiotoxicity. Bisantrene has recently been identified a potent (IC50 142nM) Fat Mass and Obesity (FTO) associated protein a m6A RNA demethylase.
| Property | Value |
|---|---|
| dbo:abstract | Bisantrene, trademarked as Zantrene, is an with anthracycline-like antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike anthracyclines like doxorubicin, exhibits little cardiotoxicity. Bisantrene has recently been identified a potent (IC50 142nM) Fat Mass and Obesity (FTO) associated protein a m6A RNA demethylase. Bisantrene is currently undergoing a number of Phase II trials to assess the efficacy of fighting hard to target cancers and understand any negative side effects that could occur. (en) |
| dbo:casNumber | 78186-34-2 |
| dbo:chEBI | 88337 |
| dbo:chEMBL | 25336 |
| dbo:fdaUniiCode | 39C34M111K |
| dbo:kegg | D03130 |
| dbo:pubchem | 51323 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Bisantrene.png?width=300 |
| dbo:wikiPageExternalLink | https://www.cancer.gov/ |
| dbo:wikiPageID | 67126169 (xsd:integer) |
| dbo:wikiPageLength | 14226 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1096901304 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Breast_cancer dbr:Anthracycline dbr:DNA dbr:In_vitro dbr:Rash dbr:Stomatitis dbc:Anthracenes dbc:Imidazoles dbr:N6-Methyladenosine dbr:Antineoplastic dbr:Leukemia dbr:Acute_myeloid_leukemia dbr:American_Cyanamid dbr:Doxorubicin dbr:Cardiotoxicity dbr:Vomiting dbr:Hair_loss dbr:Chemotherapy dbc:Hydrazones dbr:Bone_marrow_suppression dbr:City_of_Hope_National_Medical_Center dbr:FTO_gene dbr:Ovarian_cancer dbr:Anthracenyl |
| dbp:c | 22 (xsd:integer) |
| dbp:casNumber | 78186 (xsd:integer) |
| dbp:chebi | 88337 (xsd:integer) |
| dbp:chembl | 25336 (xsd:integer) |
| dbp:chemspiderid | 46491 (xsd:integer) |
| dbp:drugName | Bisantrene (en) |
| dbp:h | 22 (xsd:integer) |
| dbp:iupacName | N-[-[10-[-methyl]anthracen-9-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine (en) |
| dbp:kegg | D03130 (en) |
| dbp:n | 8 (xsd:integer) |
| dbp:pubchem | 51323 (xsd:integer) |
| dbp:smiles | Cc1c2ccccc2cc2ccccc12 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | NJSMWLQOCQIOPE-UHFFFAOYSA-N (en) |
| dbp:unii | 39 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Chemotherapeutic_agents dbt:Citation_needed dbt:Infobox_drug dbt:Reflist |
| dcterms:subject | dbc:Anthracenes dbc:Imidazoles dbc:Hydrazones |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug |
| rdfs:comment | Bisantrene, trademarked as Zantrene, is an with anthracycline-like antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike anthracyclines like doxorubicin, exhibits little cardiotoxicity. Bisantrene has recently been identified a potent (IC50 142nM) Fat Mass and Obesity (FTO) associated protein a m6A RNA demethylase. (en) |
| rdfs:label | Bisantrene (en) |
| owl:sameAs | wikidata:Bisantrene https://global.dbpedia.org/id/2Y4U3 |
| prov:wasDerivedFrom | wikipedia-en:Bisantrene?oldid=1096901304&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Bisantrene.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Bisantrene |
| foaf:name | Bisantrene (en) |
| is dbo:wikiPageWikiLink of | dbr:List_of_drugs:_Bi–Bo |
| is foaf:primaryTopic of | wikipedia-en:Bisantrene |
