Blasticidin S (original) (raw)
Blasticidin S ist ein Nukleosid-Antibiotikum und Fungizid aus aus der Gruppe der Aminoacylnukleoside.
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| dbo:abstract | Blasticidin S ist ein Nukleosid-Antibiotikum und Fungizid aus aus der Gruppe der Aminoacylnukleoside. (de) Blasticidin S is an antibiotic that is used in biology research for selecting cells in cell culture. Cells of interest can express the blasticidin resistance genes BSD or bsr, and can then survive treatment with the antibiotic. Blasticidin S is a nucleoside analogue antibiotic, resembling the nucleoside cytidine. Blasticidin works against human cells, fungi, and bacteria, all by disrupting protein translation. It was originally described by Japanese researchers in the 1950s seeking antibiotics for rice blast fungus. (en) La blasticidine S est un antibiotique produit par Streptomyces griseochromogenes . En recherche biologique, en particulier en génie génétique, il est utilisé pour sélectionner des cellules ayant incorporé une modification génétique d'intérêt. En bref, l'ADN d'intérêt est fusionné à l'ADN codant la résistance à la blasticidine, puis introduit dans les cellules. Après avoir laissé le temps aux cellules de transcrire et traduire leur nouvel ADN, de la blasticidine est ajoutée. De la sorte, seules les cellules possédant le nouvel ADN peuvent se développer. (fr) ブラストサイジンS（英: Blasticidin S）は抗生物質の一種で、主に農業用殺菌剤として使われた。 (ja) Blasticidina S é um antibiótico que é produzido por . Na pesquisa biológica, especificamente naengenharia genética, ele é utilizado para selecionar células transformadas que foram projetados para transportar um gene com resistência à blasticidina. Em suma, o DNA de interesse é fusionado ao DNA que codifica um gene de resistência, e, em seguida, é transformado às células de interesse. Depois de dar tempo para a recuperação e para que as células comecem a transcrição e tradução de seus novos DNA, a blasticidina é adicionada. Agora somente as células que tem o novo DNA pode crescer. (pt) 滅瘟素，又名殺稻瘟菌素S（Blasticidin S）是一種取自放線菌的抗生素，既能殺死原核生物，也能殺死真核生物。滅瘟素能通過核糖體途徑同時抑制原核生物和真核生物的蛋白質合成進而起殺傷作用。在分子細胞生物學研究中，常常作爲篩選滅瘟素抗性細胞的藥物來使用。滅溫素最早於1950年代由日本科學家發現，當時，科學家發現這種物質能殺滅由真菌稻瘟菌引起的稻瘟，該物質也因此得名滅瘟素。 (zh) |
| dbo:iupacName | (2S,3S,6R)-3-{(3S)-3-Amino-5-[carbamimidoyl(methyl)amino]pentanamido}-6-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,6-dihydro-2H-pyran-2-carboxylic acid (en) |
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| dct:subject | dbc:Eukaryotic_selection_compounds dbc:Guanidines dbc:Pyrimidones dbc:Genetic_engineering dbc:Protein_synthesis_inhibitor_antibiotics |
| gold:hypernym | dbr:Antibiotic |
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| rdfs:comment | Blasticidin S ist ein Nukleosid-Antibiotikum und Fungizid aus aus der Gruppe der Aminoacylnukleoside. (de) Blasticidin S is an antibiotic that is used in biology research for selecting cells in cell culture. Cells of interest can express the blasticidin resistance genes BSD or bsr, and can then survive treatment with the antibiotic. Blasticidin S is a nucleoside analogue antibiotic, resembling the nucleoside cytidine. Blasticidin works against human cells, fungi, and bacteria, all by disrupting protein translation. It was originally described by Japanese researchers in the 1950s seeking antibiotics for rice blast fungus. (en) La blasticidine S est un antibiotique produit par Streptomyces griseochromogenes . En recherche biologique, en particulier en génie génétique, il est utilisé pour sélectionner des cellules ayant incorporé une modification génétique d'intérêt. En bref, l'ADN d'intérêt est fusionné à l'ADN codant la résistance à la blasticidine, puis introduit dans les cellules. Après avoir laissé le temps aux cellules de transcrire et traduire leur nouvel ADN, de la blasticidine est ajoutée. De la sorte, seules les cellules possédant le nouvel ADN peuvent se développer. (fr) ブラストサイジンS（英: Blasticidin S）は抗生物質の一種で、主に農業用殺菌剤として使われた。 (ja) Blasticidina S é um antibiótico que é produzido por . Na pesquisa biológica, especificamente naengenharia genética, ele é utilizado para selecionar células transformadas que foram projetados para transportar um gene com resistência à blasticidina. Em suma, o DNA de interesse é fusionado ao DNA que codifica um gene de resistência, e, em seguida, é transformado às células de interesse. Depois de dar tempo para a recuperação e para que as células comecem a transcrição e tradução de seus novos DNA, a blasticidina é adicionada. Agora somente as células que tem o novo DNA pode crescer. (pt) 滅瘟素，又名殺稻瘟菌素S（Blasticidin S）是一種取自放線菌的抗生素，既能殺死原核生物，也能殺死真核生物。滅瘟素能通過核糖體途徑同時抑制原核生物和真核生物的蛋白質合成進而起殺傷作用。在分子細胞生物學研究中，常常作爲篩選滅瘟素抗性細胞的藥物來使用。滅溫素最早於1950年代由日本科學家發現，當時，科學家發現這種物質能殺滅由真菌稻瘟菌引起的稻瘟，該物質也因此得名滅瘟素。 (zh) |
| rdfs:label | Blasticidin S (de) Blasticidin S (en) Blasticidine S (fr) ブラストサイジンS (ja) Blasticidina s (pt) 滅瘟素 (zh) |
| owl:sameAs | freebase:Blasticidin S yago-res:Blasticidin S wikidata:Blasticidin S dbpedia-de:Blasticidin S dbpedia-fr:Blasticidin S dbpedia-ja:Blasticidin S dbpedia-pt:Blasticidin S dbpedia-sh:Blasticidin S dbpedia-sr:Blasticidin S dbpedia-tr:Blasticidin S dbpedia-zh:Blasticidin S https://global.dbpedia.org/id/4ZbDB |
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