Buclizine (original) (raw)
Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine. In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare for migraines.
| Property | Value |
|---|---|
| dbo:abstract | Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine. In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare for migraines. (en) La buclizine est un antihistaminique dérivé de la pipérazine. Elle a des propriétés antihistaminiques, par antagonisme des récepteurs histaminique H1, anticholinergiques, par antagonisme des récepteurs muscariniques de l’acétylcholine, et adrénolytiques. Elle occasionne un effet sédatif marqué. Elle a été commercialisé en France sous le nom "Aphilan" pour le traitement des manifestations allergiques (rhinite, conjonctivite, urticaire). Elle a été aussi utilisée comme antiémétique et comme antivertigineux (hors AMM). Elle n'est plus commercialisé depuis 2008 (en France).La buclizine est considérée être un antiémétique similaire à la méclozine. (fr) ブクリジン(Buclizine)は、ピペリジン誘導体の抗ヒスタミン薬及び抗コリン薬である。メクリジンに似た制吐薬になると考えられている。 イギリスでは、McNeil Consumer Healthcareが偏頭痛の患者向けに市販するMigraleve錠に含まれる3つの成分の1つである。 (ja) Buclizina também conhecido pelo nome comercial Buclina é um antiemético, inibidor de receptores de histamina H1. É utilizado em situações de enjoo, em viagens de navio, avião, ônibus ou qualquer outra que provoque esta sensação. O medicamento não pode ser utilizado em grávidas ou que estão no período de aleitamento materno, pois ocorre risco de teratogenia no feto. É também um estimulante do apetite. (pt) |
| dbo:casNumber | 82-95-1 |
| dbo:chEBI | 3205 |
| dbo:chEMBL | 1201271 |
| dbo:drugbank | DB00354 |
| dbo:fdaUniiCode | 0C94V6X681 |
| dbo:pubchem | 6729 |
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| dbp:chembl | 1201271 (xsd:integer) |
| dbp:chemspiderid | 6473 (xsd:integer) |
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| dbp:smiles | Clc1cccCN3CCNCc4cccCC (en) |
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| dbp:verifiedfields | changed (en) |
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| dcterms:subject | dbc:Muscarinic_antagonists dbc:Tert-butyl_compounds dbc:Chlorcyclizines |
| gold:hypernym | dbr:Antihistamine |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Agent114778436 yago:CausalAgent100007347 yago:Communication100033020 yago:Drug103247620 yago:Formula106816935 yago:Matter100020827 yago:Medicine103740161 yago:Message106598915 yago:MolecularFormula106817173 yago:PhysicalEntity100001930 yago:Piperazine103946814 dbo:Drug yago:Statement106722453 yago:Substance100020090 yago:Vermifuge104528630 yago:WikicatPiperazines umbel-rc:DrugProduct |
| rdfs:comment | Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine. In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare for migraines. (en) La buclizine est un antihistaminique dérivé de la pipérazine. Elle a des propriétés antihistaminiques, par antagonisme des récepteurs histaminique H1, anticholinergiques, par antagonisme des récepteurs muscariniques de l’acétylcholine, et adrénolytiques. Elle occasionne un effet sédatif marqué. Elle a été commercialisé en France sous le nom "Aphilan" pour le traitement des manifestations allergiques (rhinite, conjonctivite, urticaire). Elle a été aussi utilisée comme antiémétique et comme antivertigineux (hors AMM). Elle n'est plus commercialisé depuis 2008 (en France).La buclizine est considérée être un antiémétique similaire à la méclozine. (fr) ブクリジン(Buclizine)は、ピペリジン誘導体の抗ヒスタミン薬及び抗コリン薬である。メクリジンに似た制吐薬になると考えられている。 イギリスでは、McNeil Consumer Healthcareが偏頭痛の患者向けに市販するMigraleve錠に含まれる3つの成分の1つである。 (ja) Buclizina também conhecido pelo nome comercial Buclina é um antiemético, inibidor de receptores de histamina H1. É utilizado em situações de enjoo, em viagens de navio, avião, ônibus ou qualquer outra que provoque esta sensação. O medicamento não pode ser utilizado em grávidas ou que estão no período de aleitamento materno, pois ocorre risco de teratogenia no feto. É também um estimulante do apetite. (pt) |
| rdfs:label | Buclizine (en) Buclizine (fr) ブクリジン (ja) Buclizina (pt) |
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