| dbo:abstract |
CCL9 (englisch CC-chemokine ligand 9) ist ein Zytokin aus der Familie der CC-Chemokine. (de) Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family. It is also called macrophage inflammatory protein-1 gamma (MIP-1γ), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18, that has been described in rodents. CCL9 has also been previously designated CCL10, although this name is no longer in use. It is secreted by follicle-associated epithelium (FAE) such as that found around Peyer's patches, and attracts dendritic cells that possess the cell surface molecule CD11b and the chemokine receptor CCR1. CCL9 can activate osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in bone resorption. CCL9 is constitutively expressed in macrophages and myeloid cells. The gene for CCL9 is located on chromosome 11 in mice. CCL9 is a chemokine involved in the process of signaling an antileukemic response and is a potential form of immunotherapy for chronic myelogenous leukemia (CML). CML is a type of cancer in which the bone marrow produces too many red blood cells. This is caused by chromosomal translocation, a mutation in which the abnormal gene BCR-ABL, is turned into a CML cell. CML starts off as a myeloproliferative for example in sickle cell anemia or extreme granulocytosis but if left untreated, it could transform into an acute form of leukemia. In order to treat CML, alpha and beta interferons (INFs) are used to regulate the process of binding the protein ICSBP to the gene BCR-ABL. CCL9 was proved to be a gene induced by ICSBP and IFN alpha and also a requirement in the expression of ICSBP in BCR-ABL transformed cells to generate an anti-leukemic immune protection via experimentation. CCL6 and CCL9 were overexpressed in BaF3 cells and injected with BCR-ABL into syngeneic mice. Although the mice still developed leukemia, it delayed the advancement of the disease by several weeks proving that CCL6 and CCL9 contribute to the creation of an anti-leukemic response within infected cells. (en) CCL9（英語：Chemokine (C-C motif) ligand 9）是一个小型的细胞因子，属于CC趋化因子家族。它的别名有巨噬细胞炎性蛋白-1γ（英語：macrophage inflammatory protein-1 gamma，MIP-1γ）, 巨噬细胞炎症蛋白相关蛋白-2（英語：macrophage inflammatory protein-related protein-2，MRP-2）以及在啮齿类中使用的CCF18。CCL9还曾经被定名为CCL10，但这个名称已不再使用。 它由淋巴结相关上皮组织（FAE）分泌（如周围），并影响拥有细胞表面分子与趋化因子受体的树突状细胞。 CCL9 通过其受体CCR1（破骨细胞中最丰富的趋化因子受体）激活破骨细胞，表明了CCL9可能在中的重要作用。CCL9巨噬细胞和骨髓细胞里也持续表达。编码CCL9的基因位于小鼠的11号染色体上。 (zh) |
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| dbo:wikiPageWikiLink |
dbr:Epithelium dbr:Cytokine dbr:Integrin_alpha_M dbr:Peyer's_patch dbr:Chemokine_receptor dbr:Chronic_myelogenous_leukemia dbr:Gene dbr:Osteoclast dbr:Dendritic_cell dbc:Cytokines dbr:Chromosomal_translocation dbr:Chromosome dbr:Granulocytosis dbr:Lymph_follicle dbr:Chemokine dbr:Bone_resorption dbr:CC_chemokine_receptors dbr:Macrophage dbr:Myeloid dbr:Sickle_cell_anemia dbr:Myeloproliferation |
| dbp:date |
February 2018 (en) |
| dbp:sure |
y (en) |
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dbt:Chemokines dbt:Infobox_gene dbt:Protein-stub dbt:Reflist dbt:Short_description dbt:Unreliable_medical_source dbt:Chemokine_receptor_modulators |
| dct:subject |
dbc:Cytokines |
| gold:hypernym |
dbr:Cytokine |
| rdf:type |
owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 yago:WikicatCytokines yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Cytokine114828193 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 dbo:HumanGene dbo:Protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment |
CCL9 (englisch CC-chemokine ligand 9) ist ein Zytokin aus der Familie der CC-Chemokine. (de) CCL9（英語：Chemokine (C-C motif) ligand 9）是一个小型的细胞因子，属于CC趋化因子家族。它的别名有巨噬细胞炎性蛋白-1γ（英語：macrophage inflammatory protein-1 gamma，MIP-1γ）, 巨噬细胞炎症蛋白相关蛋白-2（英語：macrophage inflammatory protein-related protein-2，MRP-2）以及在啮齿类中使用的CCF18。CCL9还曾经被定名为CCL10，但这个名称已不再使用。 它由淋巴结相关上皮组织（FAE）分泌（如周围），并影响拥有细胞表面分子与趋化因子受体的树突状细胞。 CCL9 通过其受体CCR1（破骨细胞中最丰富的趋化因子受体）激活破骨细胞，表明了CCL9可能在中的重要作用。CCL9巨噬细胞和骨髓细胞里也持续表达。编码CCL9的基因位于小鼠的11号染色体上。 (zh) Chemokine (C-C motif) ligand 9 (CCL9) is a small cytokine belonging to the CC chemokine family. It is also called macrophage inflammatory protein-1 gamma (MIP-1γ), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18, that has been described in rodents. CCL9 has also been previously designated CCL10, although this name is no longer in use. It is secreted by follicle-associated epithelium (FAE) such as that found around Peyer's patches, and attracts dendritic cells that possess the cell surface molecule CD11b and the chemokine receptor CCR1. CCL9 can activate osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in bone resorption. CCL9 is constitutively expressed in macrophages and myeloid cell (en) |
| rdfs:label |
CCL9 (de) CCL9 (en) CCL9 (zh) |
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wikipedia-en:CCL9?oldid=1116603675&ns=0 |
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wikipedia-en:CCL9 |
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