CLDN16 (original) (raw)
Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as
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| dbo:abstract | Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and kidney failure. (en) CLDN16 (англ. Claudin 16) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 305 амінокислот, а молекулярна маса — 33 836. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у таких біологічних процесах як транспорт іонів, транспорт. Білок має сайт для зв'язування з іоном магнію. Локалізований у клітинній мембрані, мембрані, клітинних контактах, щільних контактах. (uk) |
| dbo:wikiPageExternalLink | https://boris.unibe.ch/20922/ https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 |
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| dbo:wikiPageWikiLink | dbr:Mutant dbr:Hypercalciuria dbr:Indirect_calorimetry dbr:International_Knockout_Mouse_Consortium dbr:Gene dbr:Homozygote dbr:Urolithiasis dbr:Claudin dbr:Clinical_chemistry dbr:Hot_plate_test dbr:Peripheral_blood_lymphocyte dbr:Micronucleus_test dbc:Genes_mutated_in_mice dbr:Dual-energy_X-ray_absorptiometry dbr:Glucose_tolerance_test dbr:Kidney_failure dbr:Knockout_mouse dbr:Protein dbr:Haematology dbr:Hypomagnesemia dbr:Model_organism dbr:Salmonella dbr:Auditory_brainstem_response dbr:Citrobacter dbr:Radiography dbr:Nephrocalcinosis dbr:Open_Field_(animal_test) dbr:Dysmorphology dbr:Phenotypic_screen |
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| dcterms:subject | dbc:Genes_mutated_in_mice |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 yago:Abstraction100002137 yago:Arrangement107938773 yago:Gene105436752 yago:Group100031264 yago:Ordering108456993 yago:WikicatGenesMutatedInMice dbo:HumanGene dbo:Protein yago:Sequence108459252 yago:Series108457976 |
| rdfs:comment | Claudin-16 is a protein that in humans is encoded by the CLDN16 gene. It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as (en) CLDN16 (англ. Claudin 16) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 305 амінокислот, а молекулярна маса — 33 836. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | CLDN16 (en) CLDN16 (uk) |
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| prov:wasDerivedFrom | wikipedia-en:CLDN16?oldid=1116186551&ns=0 |
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| is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_1 dbr:Magnesium_deficiency dbr:Magnesium_transporter dbr:Claudin dbr:Cldn16 dbr:List_of_OMIM_disorder_codes dbr:Tight_junction_proteins dbr:CLDN16_(gene) |
| is foaf:primaryTopic of | wikipedia-en:CLDN16 |