CLEC6A (original) (raw)
Dectin-2 or C-type lectin domain containing 6A is a protein that in humans is encoded by the CLEC6A gene. Dectin-2 is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded protein is a type II transmembrane protein with an extracellular carbohydrate recognition domain. It functions as a pattern recognition receptor recognizing α-mannans and as such plays an important role in innate immune response to fungi. Expression is found on macrophages and dendritic cells. It can also be found at low levels in Langerhans cells and peripheral blood monocytes, where expression levels could be increased upon induction of inflammation.
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| dbo:abstract | Dectin-2 or C-type lectin domain containing 6A is a protein that in humans is encoded by the CLEC6A gene. Dectin-2 is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded protein is a type II transmembrane protein with an extracellular carbohydrate recognition domain. It functions as a pattern recognition receptor recognizing α-mannans and as such plays an important role in innate immune response to fungi. Expression is found on macrophages and dendritic cells. It can also be found at low levels in Langerhans cells and peripheral blood monocytes, where expression levels could be increased upon induction of inflammation. Dectin-2 genes are located in the telomeric region of the natural killer gene cluster on mouse chromosome 6 and human chromosome 12. The dectin-2 cluster is composed of genes encoding dectin-2, DCIR, DCAR, BDCA-2, Mincle and Clecsf8, which are the members of the group II C-type lectin family. (en) CLEC6A (англ. C-type lectin domain containing 6A) – білок, який кодується однойменним геном, розташованим у людей на 12-й хромосомі. Довжина поліпептидного ланцюга білка становить 209 амінокислот, а молекулярна маса — 23 998. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у таких біологічних процесах, як адаптивний імунітет, імунітет, вроджений імунітет, альтернативний сплайсинг. Білок має сайт для зв'язування з лектинами. Локалізований у мембрані. (uk) |
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| dbo:wikiPageWikiLink | dbr:Cytokine dbr:Interleukin_12 dbr:Interleukin_1_beta dbr:Interleukin_23 dbr:Interleukin_33 dbr:Interleukin_6 dbr:Saccharomyces_cerevisiae dbr:Phagocytosis dbr:NF-κB dbr:Cryptococcus_neoformans dbr:Dendritic_cell dbr:Fc_receptor dbr:House_dust_mite dbr:Pattern_recognition_receptor dbc:C-type_lectins dbr:Langerhans_cell dbr:Histoplasma_capsulatum dbr:Chemokine dbr:Aspergillus_fumigatus dbr:BCL10 dbr:C-type_lectin dbr:CARD9 dbr:IL17A dbr:Interferon_gamma dbr:Candida_albicans dbr:Candida_glabrata dbr:MALT1 dbr:Macrophage dbr:Tyrosine-protein_kinase_SYK dbr:Neutrophil dbr:IL17RC dbr:Th2 dbr:Mycobacterium_tuberculosis dbr:T_helper_17_cell dbr:Paracoccidioides_brasiliensis dbr:Dectin_1 dbr:Innate_immune_response dbr:Th1_lymphocytes |
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| rdfs:comment | Dectin-2 or C-type lectin domain containing 6A is a protein that in humans is encoded by the CLEC6A gene. Dectin-2 is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded protein is a type II transmembrane protein with an extracellular carbohydrate recognition domain. It functions as a pattern recognition receptor recognizing α-mannans and as such plays an important role in innate immune response to fungi. Expression is found on macrophages and dendritic cells. It can also be found at low levels in Langerhans cells and peripheral blood monocytes, where expression levels could be increased upon induction of inflammation. (en) CLEC6A (англ. C-type lectin domain containing 6A) – білок, який кодується однойменним геном, розташованим у людей на 12-й хромосомі. Довжина поліпептидного ланцюга білка становить 209 амінокислот, а молекулярна маса — 23 998. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | CLEC6A (en) CLEC6A (uk) |
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| is dbo:wikiPageWikiLink of | dbr:Dectin-2 dbr:List_of_human_protein-coding_genes_1 dbr:Pattern_recognition_receptor dbr:C-type_lectin |
| is foaf:primaryTopic of | wikipedia-en:CLEC6A |