CMAH (original) (raw)
Cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah) is an enzyme that is encoded by the CMAH gene. In most mammals, the enzyme hydroxylates N-acetylneuraminic acid (Neu5Ac), producing N-glycolylneuraminic acid (Neu5Gc). Neu5Ac and Neu5Gc are mammalian glycans that compose the glycocalyx, especially in sialoglycoproteins, which are part of the sialic acid family. The CMAH equivalent in humans is a pseudogene (CMAHP); there is no detectable Neu5Gc in normal human tissue. This deficiency has a number of proposed effects on humans, including increased brain growth and improved self-recognition by the human immune system. Incorporation of Neu5Gc from red meat and dairy into human tissues has been linked to chronic disease, including type-2 diabetes and chronic inflammation.
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| dbo:abstract | Cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah) is an enzyme that is encoded by the CMAH gene. In most mammals, the enzyme hydroxylates N-acetylneuraminic acid (Neu5Ac), producing N-glycolylneuraminic acid (Neu5Gc). Neu5Ac and Neu5Gc are mammalian glycans that compose the glycocalyx, especially in sialoglycoproteins, which are part of the sialic acid family. The CMAH equivalent in humans is a pseudogene (CMAHP); there is no detectable Neu5Gc in normal human tissue. This deficiency has a number of proposed effects on humans, including increased brain growth and improved self-recognition by the human immune system. Incorporation of Neu5Gc from red meat and dairy into human tissues has been linked to chronic disease, including type-2 diabetes and chronic inflammation. (en) La cytidine monophosphate-acide N-acétylneuraminique hydroxylase (CMAH) est une enzyme codée par le gène CMAHP. Chez la plupart des mammifères, elle hydroxyle l'acide N-acétylneuraminique (Neu5Ac) en acide N-glycolylneuraminique (Neu5Gc). Neu5Ac et Neu5Gc sont présents sur des protéines de la surface cellulaire chez les mammifères et font partie des acides sialiques. Chez l'homme, il n'existe qu'un pseudogène CMAHP. Il n'y a normalement pas de concentration détectable de Neu5Gc dans les tissus humains, ce qui pourrait avoir plusieurs conséquences sur la physiologie humaine, comme une meilleure croissance du cerveau et une meilleure auto-reconnaissance par le système immunitaire. L'absorption de Neu5Gc à partir de viande rouge et de produits laitiers a été associée des maladies chroniques telles que diabète de type 2 et inflammation chronique. (fr) |
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| rdfs:comment | Cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah) is an enzyme that is encoded by the CMAH gene. In most mammals, the enzyme hydroxylates N-acetylneuraminic acid (Neu5Ac), producing N-glycolylneuraminic acid (Neu5Gc). Neu5Ac and Neu5Gc are mammalian glycans that compose the glycocalyx, especially in sialoglycoproteins, which are part of the sialic acid family. The CMAH equivalent in humans is a pseudogene (CMAHP); there is no detectable Neu5Gc in normal human tissue. This deficiency has a number of proposed effects on humans, including increased brain growth and improved self-recognition by the human immune system. Incorporation of Neu5Gc from red meat and dairy into human tissues has been linked to chronic disease, including type-2 diabetes and chronic inflammation. (en) La cytidine monophosphate-acide N-acétylneuraminique hydroxylase (CMAH) est une enzyme codée par le gène CMAHP. Chez la plupart des mammifères, elle hydroxyle l'acide N-acétylneuraminique (Neu5Ac) en acide N-glycolylneuraminique (Neu5Gc). Neu5Ac et Neu5Gc sont présents sur des protéines de la surface cellulaire chez les mammifères et font partie des acides sialiques. Chez l'homme, il n'existe qu'un pseudogène CMAHP. Il n'y a normalement pas de concentration détectable de Neu5Gc dans les tissus humains, ce qui pourrait avoir plusieurs conséquences sur la physiologie humaine, comme une meilleure croissance du cerveau et une meilleure auto-reconnaissance par le système immunitaire. L'absorption de Neu5Gc à partir de viande rouge et de produits laitiers a été associée des maladies chroniques t (fr) |
| rdfs:label | CMAH (en) CMAH (fr) |
| rdfs:seeAlso | dbr:Blood_type_(non-human) |
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