Calcitroic acid (original) (raw)
حمض الكالسيترويك (Calcitroic acid) وهو مستقلب من الكالسيتريول (1α,25-dihydroxyvitamin D3). يتم تشكلة بتحفيز من إنزيم (كالسيتريول 24-هيدروكسيلاز). يعتبر حمض الكالسيترويك قابل للذوبان بالماء ويطرح مع البول.
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| dbo:abstract | حمض الكالسيترويك (Calcitroic acid) وهو مستقلب من الكالسيتريول (1α,25-dihydroxyvitamin D3). يتم تشكلة بتحفيز من إنزيم (كالسيتريول 24-هيدروكسيلاز). يعتبر حمض الكالسيترويك قابل للذوبان بالماء ويطرح مع البول. (ar) Calcitroic acid (1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3) is a major metabolite of 1α,25-dihydroxyvitamin D3 (calcitriol). Often synthesized in the liver and kidneys, calcitroic acid is generated in the body after vitamin D is first converted into calcitriol, an intermediate in the fortification of bone through the formation and regulation of calcium in the body. During this deactivation process, oxidation reactions at C24 and C23 occur which ultimately lead to side-chain cleavage which helps in the formation of calcitroic acid. These pathways managed by calcitriol are thought to be inactivated through its hydroxylation by the enzyme CYP24A1, also called calcitriol 24-hydroxylase. Specifically, it is thought to be the major route to inactivate vitamin D metabolites. Hydroxylation and further metabolism of calcitriol in the liver and the kidneys yields calcitroic acid, a water soluble compound that is excreted in bile. A recent review suggested that current knowledge of calcitroic acid is limited, and more studies are needed to identify its physiological role. Calcitroic acid is fairly newly introduced in studies considering it was isolated and characterized approximately 40 years ago. This explains why current knowledge is limited on the vitamin d metabolite. In case where a higher concentration of this acid is used in vitro, studies determined that calcitroic acid binds to vitamin D receptor (VDR) and induces gene transcription. In vivo, studies determined that calcitroic acid, along with citrulline, may be used to quantify the amount of ionizing radiation an individual has been exposed to. (en) カルシトロン酸（カルシトロンさん、Calcitroic acid (1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3)）は、ビタミンD3の活性型である1,25-ジヒドロキシコレカルシフェロール（カルシトリオール）の代謝物である。この物質は、カルシトリオール24-ヒドロキシラーゼの触媒作用によって生成される。カルシトロン酸は、水に溶け、尿中に排泄される。 (ja) L'acido calcitroico (1α-idrossi-23-carbossi-24,25,26,27-tetranorvitamina D3) è un metabolita principale della 1α, 25-diidrossivitamina D3 (calcitriolo). Spesso sintetizzato nel fegato e nei reni, l'acido calcitroico viene prodotto nel corpo dopo che la vitamina D è stata prima convertita in calcitriolo, un prodotto intermedio nella fortificazione dell'osso attraverso la formazione e la regolazione del calcio nel corpo. Si ritiene che queste vie gestite dal calcitriolo siano inattivate tramite la sua idrossilazione da parte dell'enzima CYP24A1, chiamato anche calcitriolo 24-idrossilasi. In particolare, si pensa che sia la via principale per inattivare i metaboliti della vitamina D. L'idrossilazione e l'ulteriore metabolismo del calcitriolo nel fegato e nei reni producono acido calcitroico, un composto idrosolubile che viene escreto nella bile. Una recente revisione ha suggerito che le attuali conoscenze sull'acido calcitroico sono limitate e sono necessari ulteriori studi per identificare il suo ruolo fisiologico. Nel caso in cui venga utilizzata una maggiore concentrazione di questo acido in vitro, gli studi hanno determinato che l'acido calcitroico si lega al recettore della vitamina D (VDR) e induce la trascrizione genica. In vivo, studi hanno determinato che l'acido calcitroico, insieme alla citrullina, può essere utilizzato per quantificare la quantità di radiazioni ionizzanti a cui un individuo è stato esposto. (it) |
| dbo:iupacName | (3R)-3-[(1R,3aS,4E,7aR)-4-{(2Z)-2-[(3R,5S)-3,5-Dihydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyloctahydro-1H-inden-1-yl]butanoic acid (en) |
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| dbo:wikiPageWikiLink | dbr:Calcitriol dbr:Metabolite dbr:Vitamin_D dbc:Human_metabolites dbr:Citrulline dbr:Enzyme dbc:Indenes dbc:Secosteroids dbc:Vitamin_D dbr:Ionizing_radiation dbr:Bile dbr:CYP24A1 |
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| dct:subject | dbc:Human_metabolites dbc:Indenes dbc:Secosteroids dbc:Vitamin_D |
| gold:hypernym | dbr:Metabolite |
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| rdfs:comment | حمض الكالسيترويك (Calcitroic acid) وهو مستقلب من الكالسيتريول (1α,25-dihydroxyvitamin D3). يتم تشكلة بتحفيز من إنزيم (كالسيتريول 24-هيدروكسيلاز). يعتبر حمض الكالسيترويك قابل للذوبان بالماء ويطرح مع البول. (ar) カルシトロン酸（カルシトロンさん、Calcitroic acid (1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3)）は、ビタミンD3の活性型である1,25-ジヒドロキシコレカルシフェロール（カルシトリオール）の代謝物である。この物質は、カルシトリオール24-ヒドロキシラーゼの触媒作用によって生成される。カルシトロン酸は、水に溶け、尿中に排泄される。 (ja) Calcitroic acid (1α-hydroxy-23-carboxy-24,25,26,27-tetranorvitamin D3) is a major metabolite of 1α,25-dihydroxyvitamin D3 (calcitriol). Often synthesized in the liver and kidneys, calcitroic acid is generated in the body after vitamin D is first converted into calcitriol, an intermediate in the fortification of bone through the formation and regulation of calcium in the body. During this deactivation process, oxidation reactions at C24 and C23 occur which ultimately lead to side-chain cleavage which helps in the formation of calcitroic acid. These pathways managed by calcitriol are thought to be inactivated through its hydroxylation by the enzyme CYP24A1, also called calcitriol 24-hydroxylase. Specifically, it is thought to be the major route to inactivate vitamin D metabolites. (en) L'acido calcitroico (1α-idrossi-23-carbossi-24,25,26,27-tetranorvitamina D3) è un metabolita principale della 1α, 25-diidrossivitamina D3 (calcitriolo). Spesso sintetizzato nel fegato e nei reni, l'acido calcitroico viene prodotto nel corpo dopo che la vitamina D è stata prima convertita in calcitriolo, un prodotto intermedio nella fortificazione dell'osso attraverso la formazione e la regolazione del calcio nel corpo. Si ritiene che queste vie gestite dal calcitriolo siano inattivate tramite la sua idrossilazione da parte dell'enzima CYP24A1, chiamato anche calcitriolo 24-idrossilasi. In particolare, si pensa che sia la via principale per inattivare i metaboliti della vitamina D. (it) |
| rdfs:label | حمض الكالسيترويك (ar) Calcitroic acid (en) Acido calcitroico (it) カルシトロン酸 (ja) |
| owl:sameAs | freebase:Calcitroic acid wikidata:Calcitroic acid dbpedia-ar:Calcitroic acid http://azb.dbpedia.org/resource/کلسیترویک_اسید dbpedia-fa:Calcitroic acid dbpedia-it:Calcitroic acid dbpedia-ja:Calcitroic acid dbpedia-sh:Calcitroic acid dbpedia-sr:Calcitroic acid https://global.dbpedia.org/id/QNUD yago-res:Calcitroic acid |
| prov:wasDerivedFrom | wikipedia-en:Calcitroic_acid?oldid=1088768906&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Calcitroic_acid.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Calcitroic_acid |
| is dbo:wikiPageWikiLink of | dbr:Calcifediol dbr:Calcipotriol dbr:Calcitriol dbr:C23H34O4 dbr:CYP24A1 dbr:Vitamin_D_(disambiguation) |
| is foaf:primaryTopic of | wikipedia-en:Calcitroic_acid |
