| dbo:abstract |
فاتحات قنوات الكالسيوم (بالإنجليزية: Calcium channel openers) هي مجموعة من الأدوية التي تسهل انتقال الأيونات خلال . (ar) A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels. An example is Bay K8644, which is an analogue of nifedipine that specifically and directly activates L-type voltage-dependent calcium channels. In contrast to Bay K8644, which is not for clinical use, ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by mobilizing calcium from acidic calcium stores. This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly by neutralizing the acidic pH within lysosomes. Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels (TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type. (en) |
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dbc:Calcium_channel_openers dbr:Bay_K8644 dbr:L-type_calcium_channel dbr:Structural_analog dbr:Voltage-dependent_calcium_channel dbr:Calcium_channel dbr:Calcium_channel_blocker dbr:Drug dbr:Ion dbr:Ambroxol dbr:Nifedipine |
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dbt:Pharmacology-stub dbt:Reflist dbt:Neuromodulation dbt:Channel_openers |
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dbc:Calcium_channel_openers |
| gold:hypernym |
dbr:Drug |
| rdf:type |
dbo:Drug |
| rdfs:comment |
فاتحات قنوات الكالسيوم (بالإنجليزية: Calcium channel openers) هي مجموعة من الأدوية التي تسهل انتقال الأيونات خلال . (ar) A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels. An example is Bay K8644, which is an analogue of nifedipine that specifically and directly activates L-type voltage-dependent calcium channels. (en) |
| rdfs:label |
فاتحات قنوات الكالسيوم (ar) Calcium channel opener (en) |
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yago-res:Calcium channel opener wikidata:Calcium channel opener dbpedia-ar:Calcium channel opener https://global.dbpedia.org/id/2MjkD |
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wikipedia-en:Calcium_channel_opener?oldid=992414266&ns=0 |
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wikipedia-en:Calcium_channel_opener |
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dbr:Ion_channel dbr:Channel_modulator dbr:Channel_opener dbr:Lysosomal_storage_disease dbr:Lysosome dbr:Calcium_channel_activator dbr:Calcium_channel_agonist dbr:Calcium_channel_enhancer dbr:Calcium_channel_facilitator dbr:Calcium_channel_openers |
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wikipedia-en:Calcium_channel_opener |