| dbo:abstract |
Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development. Calu-3 cells are epithelial and can act as respiratory models in preclinical applications. Calu-3 cells were first derived in 1975 by Germain Trempe and Jorgen Fogh of the Memorial Sloan Kettering Cancer Center. The cells were isolated from the pleural effusion of a 25-year-old Caucasian male with a lung adenocarcinoma. The Calu-3 cell line grows as an adherent monolayer and overexpresses the ERBB2 gene, leading to active ErbB2/Her2. The cells also express CK7, occludin, and E-cadherin. Calu-3 cells also have large amounts of cystic fibrosis transmembrane conductance regulator. Calu-3 cells are commonly used as both in vitro and in vivo models for drug development against lung cancer. The cells have been used in studies of pulmonary drug delivery, demonstrating a capacity to intake low molecular weight substances. Calu-3 cells have served as respiratory models for air intake and lung injury due to their responsiveness to foreign substances. The Calu-3 cell line has shown to be useful in the study of chloride ion secretion by lung epithelial cells. The cells may be used in high-throughput screening applications focused on barrier integrity and surface protein expression of lung cells. (en) Calu-3 est une lignée cellulaire de cancer du poumon humain utilisée comme modèle de cellules du système respiratoire. (fr) Calu-3是經常應用於癌症研究和藥物開發的人類肺癌細胞系，最初於1975年由紀念斯隆-凱特琳癌症中心科研人員分離自一名25歲高加索男性肺癌患者的胸腔積液。 (zh) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Trastuzumab_Fab-HER2_complex_1N8Z.png?width=300 |
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https://www.cellosaurus.org/CVCL_0609 |
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dbr:Protein_production dbc:Lung_cancer dbr:Cystic_fibrosis_transmembrane_conductance_regulator dbr:Memorial_Sloan_Kettering_Cancer_Center dbr:Lung_cancer dbr:Keratin_7 dbc:Human_cell_lines dbr:Epithelial dbr:HER2/neu dbr:Chloride dbr:High-throughput_screening dbc:1975_in_biotechnology dbr:Pleural_effusion dbr:Pulmonary dbr:Occludin dbr:E-cadherin dbr:Cell_line dbr:Lung_adenocarcinoma dbr:File:Trastuzumab_Fab-HER2_complex_1N8Z.png |
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dbt:Cn dbt:Reflist |
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dbc:Lung_cancer dbc:Human_cell_lines dbc:1975_in_biotechnology |
| rdfs:comment |
Calu-3 est une lignée cellulaire de cancer du poumon humain utilisée comme modèle de cellules du système respiratoire. (fr) Calu-3是經常應用於癌症研究和藥物開發的人類肺癌細胞系，最初於1975年由紀念斯隆-凱特琳癌症中心科研人員分離自一名25歲高加索男性肺癌患者的胸腔積液。 (zh) Calu-3 is a human lung cancer cell line commonly used in cancer research and drug development. Calu-3 cells are epithelial and can act as respiratory models in preclinical applications. Calu-3 cells were first derived in 1975 by Germain Trempe and Jorgen Fogh of the Memorial Sloan Kettering Cancer Center. The cells were isolated from the pleural effusion of a 25-year-old Caucasian male with a lung adenocarcinoma. (en) |
| rdfs:label |
Calu-3 (en) Calu-3 (fr) Calu-3細胞 (zh) |
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wikidata:Calu-3 dbpedia-fr:Calu-3 dbpedia-zh:Calu-3 https://global.dbpedia.org/id/5uqjF |
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wikipedia-en:Calu-3?oldid=1108597137&ns=0 |
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wiki-commons:Special:FilePath/Trastuzumab_Fab-HER2_complex_1N8Z.png |
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wikipedia-en:Calu-3 |
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dbr:Camostat dbr:Murine_respirovirus dbr:Cell_culture |
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wikipedia-en:Calu-3 |
