Chelatase (original) (raw)
In biochemistry, chelatases are enzymes that catalyze the insertion ("metalation") of naturally occurring tetrapyrroles. Many tetrapyrrole-based cofactors exist in nature including hemes, chlorophylls, and vitamin B12. These metallo cofactors are derived by the reaction of metal cations with tetrapyrroles, which are not ligands per se, but the conjugate acids thereof. In the case of ferrochelatases, the reaction that chelatases catalyze is: Fe2+ + H2P → FeP + 2 H+ In the above equation H2P represents a sirohydrochlorin or a porphyrin, such as protoporphyrin IX.
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| dbo:abstract | In biochemistry, chelatases are enzymes that catalyze the insertion ("metalation") of naturally occurring tetrapyrroles. Many tetrapyrrole-based cofactors exist in nature including hemes, chlorophylls, and vitamin B12. These metallo cofactors are derived by the reaction of metal cations with tetrapyrroles, which are not ligands per se, but the conjugate acids thereof. In the case of ferrochelatases, the reaction that chelatases catalyze is: Fe2+ + H2P → FeP + 2 H+ In the above equation H2P represents a sirohydrochlorin or a porphyrin, such as protoporphyrin IX. Chelatases are required because porphyrins and related macrocyclic ligands are extremely slow to metalate, despite favorable thermodynamics. These low rates are attributed to the tight fit of the metal into the rigid 18- or 17-membered tetrapyrrole macrocycle. Several families of chelatase are known including cobalt chelatase, magnesium chelatase, and ferrochelatase. Nickel insertion into a sirohydrochlorin also requires a chelatase as part of the biosynthesis of cofactor F430. Apparently that chelatase is identical to the cobalt chelatase. (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Protoporphyrin_IX.svg?width=300 |
| dbo:wikiPageID | 55658980 (xsd:integer) |
| dbo:wikiPageLength | 2540 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1120055520 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Protoporphyrin_IX dbr:Metalation dbr:Biochemistry dbr:Vitamin_B12 dbr:Cofactor_F430 dbr:Enzyme dbr:Ligand dbr:Magnesium_chelatase dbr:Chlorophyll dbr:Sirohydrochlorin dbr:Heme dbr:Macrocyclic_ligand dbc:Organometallic_chemistry dbc:Ligases dbr:Cobalt_chelatase dbr:Cofactor_(biochemistry) dbr:Ferrochelatase dbr:Tetrapyrrole dbr:File:Protoporphyrin_IX.svg |
| dbp:wikiPageUsesTemplate | dbt:Enzymes dbt:Short_description |
| dct:subject | dbc:Organometallic_chemistry dbc:Ligases |
| rdfs:comment | In biochemistry, chelatases are enzymes that catalyze the insertion ("metalation") of naturally occurring tetrapyrroles. Many tetrapyrrole-based cofactors exist in nature including hemes, chlorophylls, and vitamin B12. These metallo cofactors are derived by the reaction of metal cations with tetrapyrroles, which are not ligands per se, but the conjugate acids thereof. In the case of ferrochelatases, the reaction that chelatases catalyze is: Fe2+ + H2P → FeP + 2 H+ In the above equation H2P represents a sirohydrochlorin or a porphyrin, such as protoporphyrin IX. (en) |
| rdfs:label | Chelatase (en) |
| owl:sameAs | wikidata:Chelatase https://global.dbpedia.org/id/4WrHB |
| prov:wasDerivedFrom | wikipedia-en:Chelatase?oldid=1120055520&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Protoporphyrin_IX.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Chelatase |
| is dbo:wikiPageWikiLink of | dbr:Protoporphyrin_IX dbr:Ligase dbr:Cofactor_F430 dbr:Transition_metal_porphyrin_complexes dbr:Porphyrin |
| is foaf:primaryTopic of | wikipedia-en:Chelatase |
