Chrysiasis (original) (raw)
Chrysiasis is a dermatological condition induced by the parenteral administration of gold salts, usually for the treatment of rheumatoid arthritis. Such treatment has been superseded as the best practice for treating the disease because of "numerous side effects and monitoring requirements, their limited efficacy, and very slow onset of action". Similar to silver, a gold preparation used parenterally for a long period may rarely produce a permanent skin pigmentation – especially if the skin is exposed to sunlight or artificial ultraviolet radiation.
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| dbo:abstract | Chrysiasis is a dermatological condition induced by the parenteral administration of gold salts, usually for the treatment of rheumatoid arthritis. Such treatment has been superseded as the best practice for treating the disease because of "numerous side effects and monitoring requirements, their limited efficacy, and very slow onset of action". Similar to silver, a gold preparation used parenterally for a long period may rarely produce a permanent skin pigmentation – especially if the skin is exposed to sunlight or artificial ultraviolet radiation. The skin's pigmentation (in this condition) has been described as uniformly gray, grayish purple, slate gray, or grayish blue, and is usually limited to exposed portions of the body. It may involve the conjunctivae over the scleras but usually not the oral mucosa. Location of pigment predominantly in the upper dermis leads to the blue component of skin color through the scattering phenomenon. It is much less likely to be deposited in the nails and hair. Chrysiasis was said to have been much more common when medicines containing traces of gold were used for treatment of tuberculosis (commonplace forms of treatment nearly fifty years ago). Treatments containing gold traces were also used to treat cases of rheumatoid arthritis – but because the dose used for tuberculosis was higher than for arthritis, it has not afflicted many subscribing to such treatments. Gold can be identified in the skin chemically by light microscopy, electron microscopy, and spectroscopy. There is no way to reverse or treat chrysiasis. (en) |
| dbo:icd10 | L81.8 (ILDSL81.856) |
| dbo:wikiPageExternalLink | https://web.archive.org/web/20050825165006/http:/www.jeghers.com/annts/ARGYRIA1976.html |
| dbo:wikiPageID | 2584385 (xsd:integer) |
| dbo:wikiPageLength | 3474 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1094623831 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Sclera dbc:Gold dbr:Rheumatoid_arthritis dbr:Dermis dbr:Electron_microscopy dbr:Gold dbr:Gold_salts dbr:Oral_mucosa dbr:Silver dbr:Colloidal_gold dbr:Tuberculosis dbr:Arthritis dbc:Disturbances_of_human_pigmentation dbr:Scattering dbr:Ultraviolet dbr:Light_microscopy dbr:Parenteral dbr:ILDS dbr:Skin_lesion dbr:Pigmentation |
| dbp:icd | L81.8 (en) |
| dbp:name | Chrysiasis (en) |
| dbp:wikiPageUsesTemplate | dbt:Fact dbt:Infobox_medical_condition_(new) dbt:Medical_resources dbt:Reflist dbt:Rp dbt:Pigmentation_disorders |
| dct:subject | dbc:Gold dbc:Disturbances_of_human_pigmentation |
| gold:hypernym | dbr:Condition |
| rdf:type | owl:Thing wikidata:Q12136 yago:Abstraction100002137 yago:Act100030358 yago:Activity100407535 yago:Attribute100024264 yago:Condition113920835 yago:Disease114070360 yago:Event100029378 yago:IllHealth114052046 yago:Illness114061805 yago:PathologicalState114051917 yago:Perturbation107428450 yago:PhysicalCondition114034177 yago:PsychologicalFeature100023100 yago:YagoPermanentlyLocatedEntity dbo:Disease yago:State100024720 yago:WikicatDisturbancesOfHumanPigmentation |
| rdfs:comment | Chrysiasis is a dermatological condition induced by the parenteral administration of gold salts, usually for the treatment of rheumatoid arthritis. Such treatment has been superseded as the best practice for treating the disease because of "numerous side effects and monitoring requirements, their limited efficacy, and very slow onset of action". Similar to silver, a gold preparation used parenterally for a long period may rarely produce a permanent skin pigmentation – especially if the skin is exposed to sunlight or artificial ultraviolet radiation. (en) |
| rdfs:label | Chrysiasis (en) |
| owl:sameAs | freebase:Chrysiasis yago-res:Chrysiasis wikidata:Chrysiasis http://tt.dbpedia.org/resource/Хризиаз https://global.dbpedia.org/id/4i2rS |
| prov:wasDerivedFrom | wikipedia-en:Chrysiasis?oldid=1094623831&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Chrysiasis |
| foaf:name | Chrysiasis (en) |
| is dbo:wikiPageRedirects of | dbr:Chrysiatic |
| is dbo:wikiPageWikiLink of | dbr:Gold dbr:Argyria dbr:Gold-containing_drugs dbr:Group_11_element dbr:Carotenosis dbr:List_of_skin_conditions dbr:Chrysiatic |
| is foaf:primaryTopic of | wikipedia-en:Chrysiasis |