| dbo:abstract |
Cirazoline is a full agonist at the α1A adrenergic receptor, a partial agonist at both the α1B and α1D adrenergic receptors, and a nonselective antagonist to the α2 adrenergic receptor. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent. Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α1 adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.Administration of cirazoline also seemed to present impairment in the spatial memory of monkeys through the activation of the same receptors that showed decreased food intake in rats.However in preliminary studies, through stimulation of α2 adrenoceptors, working memory is comparatively improved. (en) |
| dbo:iupacName |
2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Cirazoline.svg?width=300 |
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| dbo:wikiPageWikiLink |
dbr:Partial_agonist dbr:Antagonist dbc:Imidazolines dbc:Phenol_ethers dbc:Alpha-2_blockers dbr:Agonist dbc:Alpha-1_adrenergic_receptor_agonists dbc:Cyclopropyl_compounds dbr:Alpha-1A_adrenergic_receptor dbr:Alpha-1B_adrenergic_receptor dbr:Alpha-1D_adrenergic_receptor dbr:Alpha-2_adrenergic_receptor dbr:Vasoconstriction dbr:Paraventricular_nucleus |
| dbp:imagefile |
Cirazoline.svg (en) |
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180 (xsd:integer) |
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2 (xsd:integer) |
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changed (en) |
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| dct:subject |
dbc:Imidazolines dbc:Phenol_ethers dbc:Alpha-2_blockers dbc:Alpha-1_adrenergic_receptor_agonists dbc:Cyclopropyl_compounds |
| gold:hypernym |
dbr:Agonist |
| rdf:type |
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| rdfs:comment |
Cirazoline is a full agonist at the α1A adrenergic receptor, a partial agonist at both the α1B and α1D adrenergic receptors, and a nonselective antagonist to the α2 adrenergic receptor. It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent. (en) |
| rdfs:label |
Cirazoline (en) |
| owl:sameAs |
freebase:Cirazoline yago-res:Cirazoline wikidata:Cirazoline http://azb.dbpedia.org/resource/سیرازولین dbpedia-fa:Cirazoline dbpedia-sh:Cirazoline dbpedia-sr:Cirazoline https://global.dbpedia.org/id/4i7dT |
| prov:wasDerivedFrom |
wikipedia-en:Cirazoline?oldid=1096659205&ns=0 |
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wiki-commons:Special:FilePath/Cirazoline.svg |
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wikipedia-en:Cirazoline |
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dbr:List_of_adrenergic_drugs dbr:Beta-adrenergic_agonist dbr:C13H16N2O dbr:Adrenergic_receptor dbr:Alpha-1_adrenergic_receptor dbr:Alpha-2_adrenergic_receptor dbr:Alpha-adrenergic_agonist dbr:List_of_drugs:_Ci |
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wikipedia-en:Cirazoline |
