Civet SARS-CoV (original) (raw)
果子貍SARS冠狀病毒（Civet SARS-CoV）是感染果子貍的嚴重急性呼吸系統綜合症相關冠狀病毒（SARSr-CoV），與感染人類、造成2002年至2003年SARS事件的严重急性呼吸道综合征冠状病毒（SARS-CoV）高度相似，基因組序列相似度約99.8%。由於疫情初期染病的幾名病人都曾在市場中與果子貍接觸，果子貍可能是人類SARS冠狀病毒的直接來源；2003年底中國廣州又有四人染疫，經序列分析發現與果子貍的病毒相似度達99.9%，亦為SARS冠狀病毒由果子貍傳染給人的案例。 後續研究普查中國各地飼養的果子貍，除少數個案外均沒有發現SARS相關病毒，顯示果子貍可能並非SARS冠狀病毒的自然宿主，僅是促使病毒從自然宿主（蝙蝠）散播至人類的中間宿主。果子貍SARS冠狀病毒雖與人類SARS冠狀病毒高度相似，但刺突蛋白的（RBD）中有少數位點差異，編碼輔助蛋白的也比人類病毒多出了一段長29nt的序列，病毒跨越物種障礙感染人類時在這些區域發生變異，可能與適應新的宿主環境有關。
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| dbo:abstract | Civet SARS-CoV is a coronavirus associated with Severe acute respiratory syndrome coronavirus (SARS-CoV), which infected humans and caused SARS events from 2002 to 2003. It infected the masked palm civet. The severe acute respiratory syndrome coronavirus (SARS-CoV) is highly similar, with a genome sequence similarity of about 99.8%. Because several patients infected at the early stage of the epidemic had contact with fruit-eating Japanese Raccoon Dog (also called tanuki) in the market, fruit-eating Tanuki may be a direct source of human SARS coronavirus. At the end of 2003, four more people in Guangzhou, China were infected with the disease. Sequence analysis found that the similarity with the Tanuki virus reached 99.9%, and the SARS coronavirus was also caused by cases of Tanuki transmission. A follow-up study of masked palm civet has not been found in a few cases, indicating that fruit tanuki may not be the natural host of SARS coronavirus, but only an intermediate host of the virus from a natural reservoir (bat) to humans. Although the tanuki SARS coronavirus is highly similar to that of human SARS coronavirus, there are a few points in the receptor binding domain (RBD) of burden protein, and the ORF8, which encoded auxiliary protein, has a long 29nt sequence than the human virus. When the virus is infected human by a species barrier, These areas change, which may be related to adapting the new environment. (en) 果子貍SARS冠狀病毒（Civet SARS-CoV）是感染果子貍的嚴重急性呼吸系統綜合症相關冠狀病毒（SARSr-CoV），與感染人類、造成2002年至2003年SARS事件的严重急性呼吸道综合征冠状病毒（SARS-CoV）高度相似，基因組序列相似度約99.8%。由於疫情初期染病的幾名病人都曾在市場中與果子貍接觸，果子貍可能是人類SARS冠狀病毒的直接來源；2003年底中國廣州又有四人染疫，經序列分析發現與果子貍的病毒相似度達99.9%，亦為SARS冠狀病毒由果子貍傳染給人的案例。 後續研究普查中國各地飼養的果子貍，除少數個案外均沒有發現SARS相關病毒，顯示果子貍可能並非SARS冠狀病毒的自然宿主，僅是促使病毒從自然宿主（蝙蝠）散播至人類的中間宿主。果子貍SARS冠狀病毒雖與人類SARS冠狀病毒高度相似，但刺突蛋白的（RBD）中有少數位點差異，編碼輔助蛋白的也比人類病毒多出了一段長29nt的序列，病毒跨越物種障礙感染人類時在這些區域發生變異，可能與適應新的宿主環境有關。 (zh) |
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| dbp:parent | Sarbecovirus (en) |
| dbp:species | SARS-related coronavirus (en) |
| dbp:strain | Civet SARS-CoV (en) |
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| rdfs:comment | 果子貍SARS冠狀病毒（Civet SARS-CoV）是感染果子貍的嚴重急性呼吸系統綜合症相關冠狀病毒（SARSr-CoV），與感染人類、造成2002年至2003年SARS事件的严重急性呼吸道综合征冠状病毒（SARS-CoV）高度相似，基因組序列相似度約99.8%。由於疫情初期染病的幾名病人都曾在市場中與果子貍接觸，果子貍可能是人類SARS冠狀病毒的直接來源；2003年底中國廣州又有四人染疫，經序列分析發現與果子貍的病毒相似度達99.9%，亦為SARS冠狀病毒由果子貍傳染給人的案例。 後續研究普查中國各地飼養的果子貍，除少數個案外均沒有發現SARS相關病毒，顯示果子貍可能並非SARS冠狀病毒的自然宿主，僅是促使病毒從自然宿主（蝙蝠）散播至人類的中間宿主。果子貍SARS冠狀病毒雖與人類SARS冠狀病毒高度相似，但刺突蛋白的（RBD）中有少數位點差異，編碼輔助蛋白的也比人類病毒多出了一段長29nt的序列，病毒跨越物種障礙感染人類時在這些區域發生變異，可能與適應新的宿主環境有關。 (zh) Civet SARS-CoV is a coronavirus associated with Severe acute respiratory syndrome coronavirus (SARS-CoV), which infected humans and caused SARS events from 2002 to 2003. It infected the masked palm civet. The severe acute respiratory syndrome coronavirus (SARS-CoV) is highly similar, with a genome sequence similarity of about 99.8%. Because several patients infected at the early stage of the epidemic had contact with fruit-eating Japanese Raccoon Dog (also called tanuki) in the market, fruit-eating Tanuki may be a direct source of human SARS coronavirus. At the end of 2003, four more people in Guangzhou, China were infected with the disease. Sequence analysis found that the similarity with the Tanuki virus reached 99.9%, and the SARS coronavirus was also caused by cases of Tanuki transmiss (en) |
| rdfs:label | Civet SARS-CoV (en) 果子貍SARS冠狀病毒 (zh) |
| owl:sameAs | wikidata:Civet SARS-CoV dbpedia-zh:Civet SARS-CoV https://global.dbpedia.org/id/Fo5N1 |
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