Conessine (original) (raw)
Conessine is a steroid alkaloid found in a number of plant species from the family Apocynaceae, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors.
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dbo:abstract | Conessine is a steroid alkaloid found in a number of plant species from the family Apocynaceae, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors. (en) La conesina es un alcaloide esteroide que se encuentra en varias especies de plantas de la familia de las apocináceas, incluidas Holarrhena floribunda, H. antidysenterica y Funtumia elastica. Actúa como antagonista de la histamina, selectiva para el subtipo H3 (con una afinidad de pKi = 8,27; Ki = ~5 nM).También se encontró que tiene largos tiempos de eliminación del Sistema nervioso central, alta penetración de la barrera hematoencefálica y alta afinidad por los receptores adrenérgicos. (es) La conessine est un composé organique de formule brute C24H40N2. (fr) |
dbo:alternativeName | Neriine; Roquessine; Wrightine; Conessinum; (3β)-N,N-Dimethyl-con-5-enin-3-amine (en) |
dbo:iupacName | (3S,3aS,5aS,5bR,9S,11aR,11bS,13aR)-N,N,2,3,11a-Pentamethyl-2,3,3a,4,5,5a,5b,6,8,9,10,11,11a,11b,12,13-hexadecahydro-1H-naphtho[2′,1′:4,5]indeno[1,7a-c]pyrrol-9-amine (en) |
dbo:thumbnail | wiki-commons:Special:FilePath/Conessine.svg?width=300 |
dbo:wikiPageID | 18693671 (xsd:integer) |
dbo:wikiPageLength | 5236 (xsd:nonNegativeInteger) |
dbo:wikiPageRevisionID | 1022025139 (xsd:integer) |
dbo:wikiPageWikiLink | dbr:Blood-brain_barrier dbr:Alkaloid dbr:Apocynaceae dbr:Funtumia_elastica dbr:Holarrhena_antidysenterica dbc:Alkaloids_found_in_Apocynaceae dbc:Steroidal_alkaloids dbr:Steroid dbc:H3_receptor_antagonists dbr:Histamine_H3_receptor dbr:Histamine_antagonist dbr:Holarrhena_floribunda |
dbp:imagefile | Conessine.svg (en) |
dbp:imagesize | 220 (xsd:integer) |
dbp:othernames | Neriine; Roquessine; Wrightine; Conessinum; -N,N-Dimethyl-con-5-enin-3-amine (en) |
dbp:pin | -N,N,2,3,11a-Pentamethyl-2,3,3a,4,5,5a,5b,6,8,9,10,11,11a,11b,12,13-hexadecahydro-1H-naphtho[2′,1′:4,5]indeno[1,7a-c]pyrrol-9-amine (en) |
dbp:verifiedfields | changed (en) |
dbp:verifiedrevid | 327756587 (xsd:integer) |
dbp:watchedfields | changed (en) |
dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Pharm-stub dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Histaminergics |
dct:subject | dbc:Alkaloids_found_in_Apocynaceae dbc:Steroidal_alkaloids dbc:H3_receptor_antagonists |
gold:hypernym | dbr:Alkaloid |
rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:Adversary109773245 yago:CausalAgent100007347 yago:LivingThing100004258 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:WikicatH3ReceptorAntagonists yago:YagoLegalActor yago:YagoLegalActorGeo dbo:ChemicalCompound yago:Whole100003553 umbel-rc:ChemicalSubstanceType |
rdfs:comment | Conessine is a steroid alkaloid found in a number of plant species from the family Apocynaceae, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors. (en) La conesina es un alcaloide esteroide que se encuentra en varias especies de plantas de la familia de las apocináceas, incluidas Holarrhena floribunda, H. antidysenterica y Funtumia elastica. Actúa como antagonista de la histamina, selectiva para el subtipo H3 (con una afinidad de pKi = 8,27; Ki = ~5 nM).También se encontró que tiene largos tiempos de eliminación del Sistema nervioso central, alta penetración de la barrera hematoencefálica y alta afinidad por los receptores adrenérgicos. (es) La conessine est un composé organique de formule brute C24H40N2. (fr) |
rdfs:label | Conesina (es) Conessine (en) Conessine (fr) |
owl:sameAs | freebase:Conessine yago-res:Conessine wikidata:Conessine dbpedia-es:Conessine dbpedia-fr:Conessine dbpedia-sh:Conessine dbpedia-sr:Conessine https://global.dbpedia.org/id/4i8YM |
prov:wasDerivedFrom | wikipedia-en:Conessine?oldid=1022025139&ns=0 |
foaf:depiction | wiki-commons:Special:FilePath/Conessine.svg |
foaf:isPrimaryTopicOf | wikipedia-en:Conessine |
is dbo:wikiPageRedirects of | dbr:C24H40N2 dbr:N,N-dimethyl-con-5-enin-3-amine |
is dbo:wikiPageWikiLink of | dbr:Funtumia_elastica dbr:Antihistamine dbr:C24H40N2 dbr:H3_receptor_antagonist dbr:Histamine_H3_receptor dbr:Hofmann–Löffler_reaction dbr:Oleandrin dbr:FIASMA dbr:N,N-dimethyl-con-5-enin-3-amine dbr:List_of_drugs:_Cm–Co |
is foaf:primaryTopic of | wikipedia-en:Conessine |