Contryphan (original) (raw)
The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2."
| Property | Value |
|---|---|
| dbo:abstract | The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2." (en) I contrifani sono una famiglia di peptidi che sono costituenti attivi del veleno prodotto da molluschi gasteropodi marini appartenenti al genere Conus. I due residui di amminoacidi cisteina presenti nei contrifani sono legati da un legame disolfuro. I contrifani subiscono un insolito grado di modificazioni post-traduzionali comprese l'epimerizzazione di triptofano e leucina, bromurazione del triptofano, ammidazione del C-terminale, e idrossilazione della prolina. (it) |
| dbo:symbol | Contryphan_CS |
| dbo:thumbnail | wiki-commons:Special:FilePath/1NXN.png?width=300 |
| dbo:wikiPageID | 13496433 (xsd:integer) |
| dbo:wikiPageLength | 6512 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1051481501 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:NMR dbr:Hydroxyproline dbr:Peptide dbr:L-type_calcium_channel dbr:Conotoxin dbr:Conus dbr:Cone_snail dbr:Conus_marmoreus dbr:Conus_purpurascens dbr:Conus_radiatus dbr:Conus_stercusmuscarum dbr:Conus_textile dbr:Conus_ventricosus dbr:Leucine dbr:Calcium-activated_potassium_channel dbr:Paralysis dbr:Post-translational_modification dbr:Tryptophan dbr:Amino_acid dbr:Cysteine dbr:Bromination dbr:Epimerization dbc:Neurotoxins dbc:Ion_channel_toxins dbr:Disulfide_bond dbr:C-terminus dbc:Snail_toxins dbr:Venom dbr:Peptide_sequence dbr:L-leucine dbr:L-tryptophan dbr:Amidation dbr:Gamma-carboxyglutamic_acid dbr:File:Textile_cone.JPG |
| dbp:caption | . (en) NMR structure of Contryphan-Vn. The peptide backbone is depicted by a curved tube while the amino acid side-chains are represented by capped sticks. Carbon atoms are colored grey, nitrogen atoms blue, oxygen atoms red, and sulfur atoms yellow. (en) |
| dbp:interpro | IPR011062 (en) |
| dbp:name | Contryphan (en) |
| dbp:pdb | , , , , (en) |
| dbp:pfam | PF02950 (en) |
| dbp:prosite | PS60027 (en) |
| dbp:scop | 2 (xsd:integer) |
| dbp:symbol | Contryphan_CS (en) |
| dbp:wikiPageUsesTemplate | dbt:MeshName dbt:Reflist dbt:PDB2 dbt:Pfam_box |
| dcterms:subject | dbc:Neurotoxins dbc:Ion_channel_toxins dbc:Snail_toxins |
| gold:hypernym | dbr:Family |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:WikicatNeurotoxins yago:Matter100020827 yago:Neurotoxin115036321 yago:PhysicalEntity100001930 yago:Poison115032376 yago:WikicatIonChannelToxins dbo:Protein yago:Substance100020090 yago:Toxin115034074 |
| rdfs:comment | The contryphans (conus + tryptophan) are a family of peptides that are active constituents of the potent venom produced by cone snail (genus Conus). The two amino acid cysteine residues in contryphans are linked by a disulfide bond. In addition, contryphans undergo an unusual degree of post-translational modification including epimerization of leucine and tryptophan, tryptophan bromination, amidation of the C-terminus, and proline hydroxylation. In the broader scheme of genetic conotoxin classification, contryphans are members of "Conotoxin Superfamily O2." (en) I contrifani sono una famiglia di peptidi che sono costituenti attivi del veleno prodotto da molluschi gasteropodi marini appartenenti al genere Conus. I due residui di amminoacidi cisteina presenti nei contrifani sono legati da un legame disolfuro. I contrifani subiscono un insolito grado di modificazioni post-traduzionali comprese l'epimerizzazione di triptofano e leucina, bromurazione del triptofano, ammidazione del C-terminale, e idrossilazione della prolina. (it) |
| rdfs:label | Contryphan (en) Contrifano (it) |
| owl:sameAs | freebase:Contryphan yago-res:Contryphan wikidata:Contryphan dbpedia-it:Contryphan https://global.dbpedia.org/id/3QPRj |
| prov:wasDerivedFrom | wikipedia-en:Contryphan?oldid=1051481501&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Textile_cone.jpg wiki-commons:Special:FilePath/1NXN.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Contryphan |
| is dbo:wikiPageWikiLink of | dbr:Conotoxin dbr:Conus_ventricosus dbr:Hebomoia_glaucippe |
| is foaf:primaryTopic of | wikipedia-en:Contryphan |
