Cord factor (original) (raw)
Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly.
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| dbo:abstract | Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly. (en) El factor cuerda o dimicolato de trehalosa, es una molécula de glucolípido encontrada en la pared de célula de Mycobacterium tuberculosis y especie similar. Es el lípido primario encontrado en el exterior de las células de M. tuberculosis. El factor cuerda influye el arreglo de células de M. tuberculosis a formaciones largas y esbeltas, dando su nombre. Este factor es virulento hacia células mamíferos y crítico para supervivencia de M. tuberculosis en anfitriones, pero no exteriores de anfitriones. El factor cuerda ha sido observado para influir respuestas inmunes, inducir la formación de granulomas, e inhibir crecimiento de tumor. El antimycobacterial fármaco SQ109 está pensado para inhibir TDM niveles de producción y de este modo interrumpe su asamblea de pared de la célula. (es) |
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| gold:hypernym | dbr:Molecule |
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| rdfs:comment | Cord factor, or trehalose dimycolate, is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. The antimycobacterial drug SQ109 is thought to inhibit TDM production levels and in this way disrupts its cell wall assembly. (en) El factor cuerda o dimicolato de trehalosa, es una molécula de glucolípido encontrada en la pared de célula de Mycobacterium tuberculosis y especie similar. Es el lípido primario encontrado en el exterior de las células de M. tuberculosis. El factor cuerda influye el arreglo de células de M. tuberculosis a formaciones largas y esbeltas, dando su nombre. Este factor es virulento hacia células mamíferos y crítico para supervivencia de M. tuberculosis en anfitriones, pero no exteriores de anfitriones. El factor cuerda ha sido observado para influir respuestas inmunes, inducir la formación de granulomas, e inhibir crecimiento de tumor. El antimycobacterial fármaco SQ109 está pensado para inhibir TDM niveles de producción y de este modo interrumpe su asamblea de pared de la célula. (es) |
| rdfs:label | Factor cuerda (es) Cord factor (en) |
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