Correlates of immunity (original) (raw)

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dbo:abstract Correlates of immunity or correlates of protection to a virus or other infectious pathogen are measurable signs that a person (or other potential host) is immune, in the sense of being protected against becoming infected and/or developing disease. For many viruses, antibodies and especially neutralizing antibodies serve as a correlate of immunity. Pregnant women, for example, are routinely screened in the UK for rubella antibodies to confirm their immunity, which can cause serious congenital abnormalities in their children. In contrast, for HIV, the simple presence of antibodies is not a correlate of immunity/protection since infected individuals develop antibodies without protection against the disease. The fact that the correlates of immunity/protection remain unclear is a significant barrier to HIV vaccine research. There is evidence that some highly exposed individuals can develop resistance to HIV infection, suggesting that immunity and therefore a vaccine is possible. However, without knowing the correlates of immunity, scientists cannot know exactly what sort of immune response a vaccine would need to stimulate, and the only method of assessing vaccine effectiveness will be through large phase III trials with clinical outcomes (i.e. infection and/or disease, not just laboratory markers). Multiple studies used predictive markers to validate higher levels of neutralizing antibodies corresponding with lower likelihood of breakthrough infection after vaccination in COVID-19. (en) 保護性關聯值(Correlates of Protection,CoP)又稱免疫性關聯值(Correlates of Immunity),可用以評估疫苗的保護效力,一般是用已完成的臨床三期受試者免疫檢驗數據訂出的一組指標閾值數值,例如中和抗體的滴度可作為指標之一。疫苗保護力不能僅看單一指標,必須參考整組數據。 免疫橋接使用免疫保護相關性(英語:immunological correlate of protection,ICP)之指標,如有關抗體或T細胞的免疫分析,比較已有疫苗和開發中疫苗,取代三期臨床試驗結果,做為新疫苗核准上市審查的依據。 (zh)
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dbo:wikiPageWikiLink dbr:Rubella dbc:Epidemiology dbr:Vaccination dbr:Vaccine dbc:Immunology dbr:Serostatus dbr:Clinical_trial dbr:Pathogen dbr:COVID-19 dbr:UK dbr:HIV dbr:Disease dbr:Antibodies dbr:Immune dbr:Virus dbr:Seroconversion dbr:Congenital dbr:Immunization dbr:Immunological_memory dbr:Neutralizing_antibodies
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rdfs:comment 保護性關聯值(Correlates of Protection,CoP)又稱免疫性關聯值(Correlates of Immunity),可用以評估疫苗的保護效力,一般是用已完成的臨床三期受試者免疫檢驗數據訂出的一組指標閾值數值,例如中和抗體的滴度可作為指標之一。疫苗保護力不能僅看單一指標,必須參考整組數據。 免疫橋接使用免疫保護相關性(英語:immunological correlate of protection,ICP)之指標,如有關抗體或T細胞的免疫分析,比較已有疫苗和開發中疫苗,取代三期臨床試驗結果,做為新疫苗核准上市審查的依據。 (zh) Correlates of immunity or correlates of protection to a virus or other infectious pathogen are measurable signs that a person (or other potential host) is immune, in the sense of being protected against becoming infected and/or developing disease. Multiple studies used predictive markers to validate higher levels of neutralizing antibodies corresponding with lower likelihood of breakthrough infection after vaccination in COVID-19. (en)
rdfs:label Correlates of immunity (en) 保護性關聯值 (zh)
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