Cryogenine (original) (raw)
Cryogenine, also known as vertine or (10α)-4,5-dimethoxy-2-hydroxylythran-12-one, is a biphenylquinolizidine lactone alkaloid from the plants Sinicuichi (Heimia salicifolia) and . The compound has no psychoactive properties in humans up to 310 mg, but has shown anti-inflammatory activity similar to aspirin. The freebase form melts at 250–251 °C and is soluble in moderately polar organic solvents such as chloroform, methylene chloride, benzene, and methanol, but is insoluble in water and petroleum ether.
| Property | Value |
|---|---|
| dbo:abstract | Cryogenine, also known as vertine or (10α)-4,5-dimethoxy-2-hydroxylythran-12-one, is a biphenylquinolizidine lactone alkaloid from the plants Sinicuichi (Heimia salicifolia) and . The compound has no psychoactive properties in humans up to 310 mg, but has shown anti-inflammatory activity similar to aspirin. The freebase form melts at 250–251 °C and is soluble in moderately polar organic solvents such as chloroform, methylene chloride, benzene, and methanol, but is insoluble in water and petroleum ether. In the development of thin layer chromatography plates with diazotized p-nitroaniline spray, cryogenine produces a purple spot (as does , another biphenylquinolizidine lactone alkaloid found in Heimia species). (en) La criogenina, también conocida como vertina o (10α)-4,5-dimetoxi-2-hidroxilitran-12-ona, es un alcaloide bifenilquinolizidina lactona que se encuentra en las plantas y . El compuesto no tiene propiedades psicoactivas en los seres humanos hasta dosis de 310 mg, pero ha demostrado una actividad antiinflamatoria similar a la aspirina. La base libre se funde a 250-251 Cº y es soluble en disolventes orgánicos moderadamente polares tales como el cloroformo, cloruro de metileno, benceno y metanol , pero es insoluble en agua y éter de petróleo. En el revelado de placas de cromatografía de capa fina con una pulverización de p-nitroanilina diazotizada, la criogenina produce una mancha púrpura (como lo hace la , otro alcaloide bifenilquinolizidina lactona que se encuentra en las especies de Heimia). (es) |
| dbo:casNumber | 10308-13-1 |
| dbo:chEMBL | 1173218 |
| dbo:fdaUniiCode | OR77C8W8TA |
| dbo:pubchem | 5315204 |
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| dbp:chembl | 1173218 (xsd:integer) |
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| dbp:smiles | O=C/4O[C@H]5C[C@@H]1N[C@H]C5 (en) |
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| dbp:unii | OR77C8W8TA (en) |
| dbp:verifiedfields | changed (en) |
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| dbp:wikiPageUsesTemplate | dbt:About dbt:Drugbox dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite |
| dct:subject | dbc:Alkaloids dbc:Alkene_derivatives dbc:Lactones dbc:Catechol_ethers |
| gold:hypernym | dbr:Alkaloid |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Alkaloid114712692 yago:Alkene114713120 yago:Chemical114806838 yago:Compound114818238 yago:Element114840755 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Substance100019613 yago:WikicatAlkaloids yago:WikicatAlkenes yago:WikicatPhenolEthers umbel-rc:DrugProduct |
| rdfs:comment | Cryogenine, also known as vertine or (10α)-4,5-dimethoxy-2-hydroxylythran-12-one, is a biphenylquinolizidine lactone alkaloid from the plants Sinicuichi (Heimia salicifolia) and . The compound has no psychoactive properties in humans up to 310 mg, but has shown anti-inflammatory activity similar to aspirin. The freebase form melts at 250–251 °C and is soluble in moderately polar organic solvents such as chloroform, methylene chloride, benzene, and methanol, but is insoluble in water and petroleum ether. (en) La criogenina, también conocida como vertina o (10α)-4,5-dimetoxi-2-hidroxilitran-12-ona, es un alcaloide bifenilquinolizidina lactona que se encuentra en las plantas y . El compuesto no tiene propiedades psicoactivas en los seres humanos hasta dosis de 310 mg, pero ha demostrado una actividad antiinflamatoria similar a la aspirina. La base libre se funde a 250-251 Cº y es soluble en disolventes orgánicos moderadamente polares tales como el cloroformo, cloruro de metileno, benceno y metanol , pero es insoluble en agua y éter de petróleo. (es) |
| rdfs:label | Criogenina (es) Cryogenine (en) |
| owl:sameAs | freebase:Cryogenine yago-res:Cryogenine wikidata:Cryogenine http://azb.dbpedia.org/resource/کریوژنین dbpedia-es:Cryogenine dbpedia-sh:Cryogenine dbpedia-sr:Cryogenine https://global.dbpedia.org/id/4if92 |
| prov:wasDerivedFrom | wikipedia-en:Cryogenine?oldid=966144853&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Cryogenine.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Cryogenine |
| is dbo:wikiPageRedirects of | dbr:C26H29NO5 dbr:Cryogenine/Vertine dbr:Vertine |
| is dbo:wikiPageWikiLink of | dbr:List_of_psychoactive_plants dbr:List_of_psychedelic_drugs dbr:C26H29NO5 dbr:Heimia dbr:Aztec_use_of_entheogens dbr:Cryogenine/Vertine dbr:Vertine |
| is foaf:primaryTopic of | wikipedia-en:Cryogenine |
