D-Deprenyl (original) (raw)
d-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor that metabolizes into d-amphetamine and d-methamphetamine and is therefore also a norepinephrine–dopamine releasing agent. It is the opposite enantiomer of l-deprenyl (selegiline). In addition to its actions as an MAO-B inhibitor and NDRA, d-deprenyl has been found to bind with high affinity to the σ1 receptor (Ki = 79 nM) similarly to various other amphetamine derivatives. Its l-isomer, selegiline, binds with 3.5-fold lower affinity in comparison.
| Property | Value |
|---|---|
| dbo:abstract | d-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor that metabolizes into d-amphetamine and d-methamphetamine and is therefore also a norepinephrine–dopamine releasing agent. It is the opposite enantiomer of l-deprenyl (selegiline). l-Deprenyl, also an MAO-B inhibitor, metabolizes to l-amphetamine and l-methamphetamine, which are both norepinephrine releasing agents. In contrast, d-deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas l-deprenyl is not known to have any appreciable psychological reinforcement. In addition to its actions as an MAO-B inhibitor and NDRA, d-deprenyl has been found to bind with high affinity to the σ1 receptor (Ki = 79 nM) similarly to various other amphetamine derivatives. Its l-isomer, selegiline, binds with 3.5-fold lower affinity in comparison. (en) D-Deprenil, também conhecido como dextro-N-propargil-N-metilanfetamina, é um inibidor da MAO-B e um pró-fármaco que se metaboliza em dextronfetamina e metanfetamina e, por isso, também atua como agente de liberação de noradrenalina e dopamina (NDRA). É o enantiômero oposto do L-Deprenil (selegilina). L-Deprenil (selegilina), também um inibidor da MAO-B, é metabolizado em em L-anfetamina e L-metanfetamina, que são dois agentes de liberação de noradrenalina. Em estudos aplicados em ratos, descobriu-se que o D-deprenil tem maior atividade dopaminérgica e potencial de efeito de reforço, enquanto o L-Deprenil não possui estímulo reforçador relevante. Além de agir como NDRA e inibidor da MAO-B, D-Deprenil possui alta afinidade com os (σ1; Ki = 79 nM), assim como outros derivados de anfetamina. Seu isômero selegilina, liga-se aos receptores sigmas com uma afinidade 3,5 vezes menor. (pt) |
| dbo:casNumber | 4528-51-2 |
| dbo:fdaUniiCode | YK7HY2RY1W |
| dbo:pubchem | 199605 |
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| dbp:drugName | -Deprenyl (en) |
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| dbp:iupacName | -N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine (en) |
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| gold:hypernym | dbr:Inhibitor |
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| rdfs:comment | d-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor that metabolizes into d-amphetamine and d-methamphetamine and is therefore also a norepinephrine–dopamine releasing agent. It is the opposite enantiomer of l-deprenyl (selegiline). In addition to its actions as an MAO-B inhibitor and NDRA, d-deprenyl has been found to bind with high affinity to the σ1 receptor (Ki = 79 nM) similarly to various other amphetamine derivatives. Its l-isomer, selegiline, binds with 3.5-fold lower affinity in comparison. (en) D-Deprenil, também conhecido como dextro-N-propargil-N-metilanfetamina, é um inibidor da MAO-B e um pró-fármaco que se metaboliza em dextronfetamina e metanfetamina e, por isso, também atua como agente de liberação de noradrenalina e dopamina (NDRA). É o enantiômero oposto do L-Deprenil (selegilina). Além de agir como NDRA e inibidor da MAO-B, D-Deprenil possui alta afinidade com os (σ1; Ki = 79 nM), assim como outros derivados de anfetamina. Seu isômero selegilina, liga-se aos receptores sigmas com uma afinidade 3,5 vezes menor. (pt) |
| rdfs:label | D-Deprenyl (en) D-Deprenil (pt) |
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| foaf:name | -Deprenyl (en) |
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