DAZ3 (original) (raw)
Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene. This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified
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| dbo:abstract | Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene. This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. (en) DAZ3 (англ. Deleted in azoospermia 3) – білок, який кодується однойменним геном, розташованим у людей на Y-хромосомі. Довжина поліпептидного ланцюга білка становить 486 амінокислот, а молекулярна маса — 54 989. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до . Задіяний у таких біологічних процесах, як диференціація клітин, сперматогенез, альтернативний сплайсинг. Білок має сайт для зв'язування з РНК. Локалізований у цитоплазмі, ядрі. (uk) |
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| dbo:wikiPageWikiLink | dbr:DAZ_protein_family dbr:Gene dbr:Protein dbr:Azoospermia_factor dbr:RNA_recognition_motif dbr:Exon dbr:Spermatogenesis dbr:Chromosome_Y dbr:Premeiotic |
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| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 dbo:HumanGene dbo:Protein |
| rdfs:comment | Deleted in azoospermia protein 3 is a protein that in humans is encoded by the DAZ3 gene. This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified (en) DAZ3 (англ. Deleted in azoospermia 3) – білок, який кодується однойменним геном, розташованим у людей на Y-хромосомі. Довжина поліпептидного ланцюга білка становить 486 амінокислот, а молекулярна маса — 54 989. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | DAZ3 (en) DAZ3 (uk) |
| owl:sameAs | freebase:DAZ3 wikidata:DAZ3 http://tt.dbpedia.org/resource/DAZ3 dbpedia-uk:DAZ3 https://global.dbpedia.org/id/jckr |
| prov:wasDerivedFrom | wikipedia-en:DAZ3?oldid=1092936044&ns=0 |
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| is dbo:wikiPageDisambiguates of | dbr:Daz |
| is dbo:wikiPageRedirects of | dbr:DAZ3_(gene) |
| is dbo:wikiPageWikiLink of | dbr:DAZ_protein_family dbr:List_of_human_protein-coding_genes_1 dbr:Daz dbr:DAZ3_(gene) dbr:Y_chromosome dbr:RNA_recognition_motif |
| is foaf:primaryTopic of | wikipedia-en:DAZ3 |