DSIF (original) (raw)

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In gene expression, DSIF (DRB Sensitivity Inducing Factor) is a protein that can either negatively or positively affect transcription by RNA polymerase II (Pol II). In one case of negative regulation, it can interact with negative elongation factor (NELF) to promote the stalling of Pol II at some genes. This stalling is relieved by P-TEFb. In humans, DSIF is composed of hSPT4 and hSPT5 (SPT4 and SPT5 are homologs in yeast). In bacteria, the homologous complex only contains NusG, a Spt5 homolog. Archaea have both proteins.

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dbo:abstract In gene expression, DSIF (DRB Sensitivity Inducing Factor) is a protein that can either negatively or positively affect transcription by RNA polymerase II (Pol II). In one case of negative regulation, it can interact with negative elongation factor (NELF) to promote the stalling of Pol II at some genes. This stalling is relieved by P-TEFb. In humans, DSIF is composed of hSPT4 and hSPT5 (SPT4 and SPT5 are homologs in yeast). The complex locks the RNAP clamp into a closed state to prevent the elongation complex (EC) from dissociating. The Spt5 helps anneal the two strands of DNA upstream. The single in bacteria and archaea anchors a ribosome to the RNAP. In bacteria, the homologous complex only contains NusG, a Spt5 homolog. Archaea have both proteins. (en)
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dbo:wikiPageWikiLink dbr:Gene_expression dbr:RNA_polymerase_II dbr:5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole dbc:Gene_expression dbr:Protein dbr:Negative_elongation_factor dbr:Ribosome dbr:SUPT4H1 dbr:P-TEFb dbr:SUPT5H dbr:KOW_domain dbr:NGN_domain
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dct:subject dbc:Gene_expression
gold:hypernym dbr:Protein
rdf:type dbo:Protein
rdfs:comment In gene expression, DSIF (DRB Sensitivity Inducing Factor) is a protein that can either negatively or positively affect transcription by RNA polymerase II (Pol II). In one case of negative regulation, it can interact with negative elongation factor (NELF) to promote the stalling of Pol II at some genes. This stalling is relieved by P-TEFb. In humans, DSIF is composed of hSPT4 and hSPT5 (SPT4 and SPT5 are homologs in yeast). In bacteria, the homologous complex only contains NusG, a Spt5 homolog. Archaea have both proteins. (en)
rdfs:label DSIF (en)
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