Dally (gene) (original) (raw)

Dally (division abnormally delayed) is the name of a gene that encodes a HS-modified-protein found in the fruit fly (Drosophila melanogaster). The protein has to be processed after being codified, and in its mature form it is composed by 626 amino acids, forming a proteoglycan rich in heparin sulfate which is anchored to the cell surface via covalent linkage to glycophosphatidylinositol (GPI), so we can define it as a glypican. For its normal biosynthesis it requires sugarless (sgl), a gene that encodes an enzyme which plays a critical role in the process of modification of dally.