| dbo:abstract |
Darifenacin ist eine organisch-chemische Verbindung aus der Klasse der Aromaten, die unter dem Handelsnamen Emselex® (Hersteller Novartis) als Arzneistoff zur Behandlung von Harninkontinenz eingesetzt wird. (de) Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis. In 2010, the US rights were sold to Warner Chilcott for US$400 million. (en) Daryfenacyna (łac. Darifenacinum) – bloker receptorów muskarynowych M3, stosowany w leczeniu zaburzeń czynnościowych pęcherza moczowego. (pl) |
| dbo:alternativeName |
Enablex, Emselex (en) |
| dbo:bioavailability |
15.000000 (xsd:float) |
| dbo:casNumber |
133099-04-4 |
| dbo:chEBI |
391960 |
| dbo:chEMBL |
1346 |
| dbo:drugbank |
DB00496 |
| dbo:fdaUniiCode |
APG9819VLM |
| dbo:kegg |
D01699 D03654 |
| dbo:medlinePlus |
a605039 |
| dbo:pubchem |
444031 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Darifenacin.svg?width=300 |
| dbo:wikiPageExternalLink |
https://druginfo.nlm.nih.gov/drugportal/name/darifenacin https://druginfo.nlm.nih.gov/drugportal/name/darifenacin%20hydrobromide |
| dbo:wikiPageID |
5310859 (xsd:integer) |
| dbo:wikiPageLength |
6170 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1095938462 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbc:Novartis_brands dbr:Urinary_bladder dbc:Benzhydryl_compounds dbc:Pyrrolidines dbr:Oral_administration dbr:Liver dbr:Muscarinic_acetylcholine_receptor dbr:Warner_Chilcott dbr:Alpha_blocker dbc:5-Benzofuranethanamines dbc:Carboxamides dbc:Muscarinic_antagonists dbr:Novartis dbr:Overactive_bladder dbr:Muscle_contraction dbr:Urinary_incontinence dbr:Urinary_retention dbc:AbbVie_brands dbr:Kidney dbr:Urinate dbr:CYP2D6 dbr:CYP3A4 dbr:Medication dbr:Heat_prostration dbr:Benign_prostatic_hypertrophy dbr:Anticholinergic_agents |
| dbp:atcPrefix |
G04 (en) |
| dbp:atcSuffix |
BD10 (en) |
| dbp:bioavailability |
15 (xsd:integer) |
| dbp:c |
28 (xsd:integer) |
| dbp:casNumber |
133099 (xsd:integer) |
| dbp:chebi |
391960 (xsd:integer) |
| dbp:chembl |
1346 (xsd:integer) |
| dbp:chemspiderid |
392054 (xsd:integer) |
| dbp:drugbank |
DB00496 (en) |
| dbp:eliminationHalfLife |
68400.0 (dbd:second) |
| dbp:excretion |
Kidney and biliary (en) |
| dbp:h |
30 (xsd:integer) |
| dbp:image |
Darifenacin-hydrobromide-from-xtal-2009-CM-3D-balls.png (en) |
| dbp:index2Label |
as salt (en) |
| dbp:iupacName |
-2 (xsd:integer) |
| dbp:iupharLigand |
321 (xsd:integer) |
| dbp:kegg |
D01699 (en) D03654 (en) |
| dbp:legalAu |
S4 (en) |
| dbp:legalEu |
Rx-only (en) |
| dbp:legalUk |
POM (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:medlineplus |
a605039 (en) |
| dbp:metabolism |
Liver (en) |
| dbp:n |
2 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pregnancyAu |
B3 (en) |
| dbp:pregnancyUs |
C (en) |
| dbp:proteinBound |
98.0 (dbd:perCent) |
| dbp:pubchem |
444031 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:smiles |
O=CC[C@H]3CNCCc5cc4ccc5 (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
HXGBXQDTNZMWGS-RUZDIDTESA-N (en) |
| dbp:tradename |
Enablex, Emselex (en) |
| dbp:unii |
APG9819VLM (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
460773728 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:wikiPageUsesTemplate |
dbt:Cite_web dbt:Drugbox dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Urologicals dbt:Drugs.com dbt:Muscarinic_acetylcholine_receptor_modulators |
| dct:subject |
dbc:Novartis_brands dbc:Benzhydryl_compounds dbc:Pyrrolidines dbc:5-Benzofuranethanamines dbc:Carboxamides dbc:Muscarinic_antagonists dbc:AbbVie_brands |
| gold:hypernym |
dbr:Medication |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAmides yago:WikicatBenzofurans yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Amide114724264 yago:Benzofuran114898101 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Statement106722453 yago:Substance100019613 umbel-rc:DrugProduct |
| rdfs:comment |
Darifenacin ist eine organisch-chemische Verbindung aus der Klasse der Aromaten, die unter dem Handelsnamen Emselex® (Hersteller Novartis) als Arzneistoff zur Behandlung von Harninkontinenz eingesetzt wird. (de) Darifenacin (trade name Enablex in United States and Canada, Emselex in the European Union) is a medication used to treat urinary incontinence due to an overactive bladder. It was discovered by scientists at the Pfizer research site in Sandwich, UK under the identifier UK-88,525 and used to be marketed by Novartis. In 2010, the US rights were sold to Warner Chilcott for US$400 million. (en) Daryfenacyna (łac. Darifenacinum) – bloker receptorów muskarynowych M3, stosowany w leczeniu zaburzeń czynnościowych pęcherza moczowego. (pl) |
| rdfs:label |
Darifenacin (de) Darifenacin (en) Daryfenacyna (pl) |
| owl:sameAs |
freebase:Darifenacin http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00496 http://www4.wiwiss.fu-berlin.de/sider/resource/drugs/72054 yago-res:Darifenacin wikidata:Darifenacin http://azb.dbpedia.org/resource/داریفناسین dbpedia-de:Darifenacin dbpedia-fa:Darifenacin dbpedia-hu:Darifenacin dbpedia-pl:Darifenacin dbpedia-sh:Darifenacin dbpedia-sr:Darifenacin https://global.dbpedia.org/id/djHX |
| prov:wasDerivedFrom |
wikipedia-en:Darifenacin?oldid=1095938462&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Darifenacin-hydrobromide-from-xtal-2009-CM-3D-balls.png wiki-commons:Special:FilePath/Darifenacin.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Darifenacin |
| is dbo:wikiPageRedirects of |
dbr:C28H30N2O2 dbr:ATC_code_G04BD10 dbr:ATCvet_code_QG04BD10 dbr:Emselex dbr:Enablex dbr:Darifenacin_hydrobromide |
| is dbo:wikiPageWikiLink of |
dbr:Vibegron dbr:Potassium_channel_blocker dbr:Muscarinic_antagonist dbr:Cholinergic_blocking_drugs dbr:Treatments_for_overactive_bladder dbr:Muscarinic_acetylcholine_receptor dbr:Muscarinic_acetylcholine_receptor_M3 dbr:C28H30N2O2 dbr:Trospium_chloride dbr:Actavis dbr:Overactive_bladder dbr:Oxybutynin dbr:ATC_code_G04BD10 dbr:ATCvet_code_QG04BD10 dbr:ATC_code_G04 dbr:Acetylcholine_receptor dbr:Solifenacin dbr:Emselex dbr:Enablex dbr:Darifenacin_hydrobromide dbr:List_of_drugs:_D–Dd |
| is foaf:primaryTopic of |
wikipedia-en:Darifenacin |
