Dauricine (original) (raw)
La dauricina, en anglès:Dauricine, és un blocador del canal de calci. La seva fórmula química és C38H44N₂O₆. És un alcaloide i la principal toxina que apareix a la planta nord-americana Menispermum canadense (moonseed) sovint la seva ingestió resulta mortal.
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| dbo:abstract | La dauricina, en anglès:Dauricine, és un blocador del canal de calci. La seva fórmula química és C38H44N₂O₆. És un alcaloide i la principal toxina que apareix a la planta nord-americana Menispermum canadense (moonseed) sovint la seva ingestió resulta mortal. (ca) Dauricin ist eine chemische Verbindung aus der Gruppe der phenolischen Isochinolin-Alkaloide. (de) Dauricine is a plant metabolite, chemically classified as a phenol, an aromatic ether, and an isoquinoline alkaloid. It has been isolated from the Asian vine Menispermum dauricum, commonly known as Asian moonseed, and the North American vine Menispermum canadense, commonly known as Canadian moonseed. Scientists Tetsuji Kametani and Keiichiro Fukumoto of Japan are credited with being the first to synthesize dauricine in 1964, using both the Arndt-Eistert reaction and Bischler-Napieralski reaction to do so. Dauricine has been studied in vitro for its potential to inhibit cancer cell growth and to block cardiac transmembrane Na+, K+, and Ca2+ ion currents. (en) Dauricina es un bloqueador de los canales de calcio. Es la toxina principal que hace venenosa a la trepadora norteamericana Menispermum canadense. (es) ダウリシン(Dauricine)は、フェノール、芳香族エーテル、イソキノリンアルカロイドに分類される植物代謝物である。どちらものつる植物であるアジアのMenispermum dauricumと北米のMenispermum canadenseから単離された。日本のとにより、アーント・アイシュタート合成とビシュラー・ナピエラルスキー反応を用いて、1964年に初めて合成された。がん細胞の成長阻害 や心臓の膜貫通Na+、K+、Ca2+イオン電流の遮断作用 についての研究がin vitroで行われている。 (ja) 蝙蝠葛鹼（英語：Dauricine）又稱作山豆根鹼，是一種鈣通道阻滯藥。它是主要的毒素使北美攀緣植物(Menispermum canadense)具有毒性（通常會致命）。 (zh) |
| dbo:iupacName | (11R,71R)-16,17,76,77-Tetramethoxy-12,72-dimethyl-11,12,13,14,71,72,73,74-octahydro-4-oxa-1,7(1)-diisoquinolina-3(1,3),5(1,4)-dibenzenaheptaphan-34-ol (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Dauricine_structure.svg?width=300 |
| dbo:wikiPageID | 20759911 (xsd:integer) |
| dbo:wikiPageLength | 4882 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1031247545 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Menispermum dbr:Metabolite dbr:Alkaloid dbc:Benzylisoquinoline_alkaloids dbr:Arndt-Eistert_reaction dbr:In_vitro dbc:Phenols dbc:Calcium_channel_blockers dbr:Bischler-Napieralski_reaction dbc:Norsalsolinol_ethers dbr:Phenol dbr:Ether |
| dbp:imagefile | Dauricine structure.svg (en) |
| dbp:imagesize | 250 (xsd:integer) |
| dbp:pin | -16177677 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Calcium_channel_blockers dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Cascite dbt:Fdacite |
| dcterms:subject | dbc:Benzylisoquinoline_alkaloids dbc:Phenols dbc:Calcium_channel_blockers dbc:Norsalsolinol_ethers |
| gold:hypernym | dbr:Metabolite |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Alkaloid114712692 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Element114840755 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 dbo:ChemicalCompound yago:Statement106722453 yago:Substance100019613 yago:WikicatAlkaloids yago:WikicatPhenolEthers yago:WikicatPhenols umbel-rc:ChemicalSubstanceType |
| rdfs:comment | La dauricina, en anglès:Dauricine, és un blocador del canal de calci. La seva fórmula química és C38H44N₂O₆. És un alcaloide i la principal toxina que apareix a la planta nord-americana Menispermum canadense (moonseed) sovint la seva ingestió resulta mortal. (ca) Dauricin ist eine chemische Verbindung aus der Gruppe der phenolischen Isochinolin-Alkaloide. (de) Dauricine is a plant metabolite, chemically classified as a phenol, an aromatic ether, and an isoquinoline alkaloid. It has been isolated from the Asian vine Menispermum dauricum, commonly known as Asian moonseed, and the North American vine Menispermum canadense, commonly known as Canadian moonseed. Scientists Tetsuji Kametani and Keiichiro Fukumoto of Japan are credited with being the first to synthesize dauricine in 1964, using both the Arndt-Eistert reaction and Bischler-Napieralski reaction to do so. Dauricine has been studied in vitro for its potential to inhibit cancer cell growth and to block cardiac transmembrane Na+, K+, and Ca2+ ion currents. (en) Dauricina es un bloqueador de los canales de calcio. Es la toxina principal que hace venenosa a la trepadora norteamericana Menispermum canadense. (es) ダウリシン(Dauricine)は、フェノール、芳香族エーテル、イソキノリンアルカロイドに分類される植物代謝物である。どちらものつる植物であるアジアのMenispermum dauricumと北米のMenispermum canadenseから単離された。日本のとにより、アーント・アイシュタート合成とビシュラー・ナピエラルスキー反応を用いて、1964年に初めて合成された。がん細胞の成長阻害 や心臓の膜貫通Na+、K+、Ca2+イオン電流の遮断作用 についての研究がin vitroで行われている。 (ja) 蝙蝠葛鹼（英語：Dauricine）又稱作山豆根鹼，是一種鈣通道阻滯藥。它是主要的毒素使北美攀緣植物(Menispermum canadense)具有毒性（通常會致命）。 (zh) |
| rdfs:label | Dauricina (ca) Dauricin (de) Dauricine (en) Dauricina (es) ダウリシン (ja) 蝙蝠葛鹼 (zh) |
| owl:sameAs | freebase:Dauricine yago-res:Dauricine wikidata:Dauricine http://azb.dbpedia.org/resource/داوریسین dbpedia-ca:Dauricine dbpedia-de:Dauricine dbpedia-es:Dauricine dbpedia-fa:Dauricine dbpedia-fi:Dauricine dbpedia-ja:Dauricine dbpedia-sh:Dauricine dbpedia-sr:Dauricine dbpedia-zh:Dauricine https://global.dbpedia.org/id/4j9L8 |
| prov:wasDerivedFrom | wikipedia-en:Dauricine?oldid=1031247545&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Dauricine_structure.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Dauricine |
| is dbo:wikiPageRedirects of | dbr:C38H44N2O6 |
| is dbo:wikiPageWikiLink of | dbr:Menispermum dbr:Menispermum_canadense dbr:Alkaloid dbr:Moscow_State_University_of_Fine_Chemical_Technologies dbr:C38H44N2O6 |
| is foaf:primaryTopic of | wikipedia-en:Dauricine |
