| dbo:abstract |
Demoxytocin (INN) (brand names Sandopart, Odeax, Sandopral), also known as desaminooxytocin or deaminooxytocin, as well as 1-(3-mercaptopropanoic acid)oxytocin ([Mpa1]OT), is an oxytocic peptide drug that is used to induce labor, promote lactation, and to prevent and treat puerperal (postpartum) mastitis (breast inflammation). Demoxytocin is a synthetic analogue of oxytocin and has similar activities, but is more potent and has a longer half-life in comparison. Unlike oxytocin, which is given via intravenous injection, demoxytocin is administered as a buccal tablet formulation. The drug was first synthesized in 1960 and was introduced into clinical practice in 1971 by Sandoz. It is marketed in several European countries, including Italy, Czech Republic, and Poland. It has the amino acid sequence Mpa-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Mpa = β-mercaptopropionic acid), and is an analogue of oxytocin wherein the leading cysteine is replaced with β-mercaptopropionic acid. (en) |
| dbo:casNumber |
113-78-0 |
| dbo:chEBI |
135900 |
| dbo:fdaUniiCode |
2N9HM3X95F |
| dbo:pubchem |
449224 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Demoxytocin.svg?width=300 |
| dbo:wikiPageID |
18765886 (xsd:integer) |
| dbo:wikiPageLength |
7191 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
992957493 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Carbetocin dbr:Sandoz dbc:Obstetric_drugs dbr:Peptide dbr:Structural_analog dbr:Intravenous_injection dbr:Mastitis dbr:Chemical_synthesis dbr:Childbirth dbr:Drug dbr:WAY-267,464 dbr:Cysteine dbr:Czech_Republic dbr:Europe dbr:Oxytocin dbc:Oxytocin_receptor_agonists dbr:Half-life dbr:International_Nonproprietary_Name dbr:Italy dbc:Peptides dbr:Labor_induction dbr:Tablet_(pharmacy) dbr:Poland dbr:Merotocin dbr:Buccal_administration dbr:TC_OT_39 dbr:Gestation dbr:Amino_acid_sequence dbr:Galactogogue dbr:Puerperal dbr:Oxytocic dbr:Β-mercaptopropionic_acid |
| dbp:atcPrefix |
H01 (en) |
| dbp:atcSuffix |
BB01 (en) |
| dbp:c |
43 (xsd:integer) |
| dbp:casNumber |
113 (xsd:integer) |
| dbp:chebi |
135900 (xsd:integer) |
| dbp:chemspiderid |
395815 (xsd:integer) |
| dbp:h |
65 (xsd:integer) |
| dbp:iupacName |
2 (xsd:integer) |
| dbp:legalStatus |
Rx-only (en) |
| dbp:n |
11 (xsd:integer) |
| dbp:o |
12 (xsd:integer) |
| dbp:pubchem |
449224 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Buccal_administration |
| dbp:s |
2 (xsd:integer) |
| dbp:smiles |
CC[C@H][C@H]1CN[C@H]CCCN (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
GTYWGUNQAMYZPF-QPLNMOKZSA-N (en) |
| dbp:synonyms |
1 (xsd:integer) ODA-914; (en) oxytoxin (en) |
| dbp:unii |
2 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Fdacite dbt:Stdinchicite dbt:Oxytocics dbt:Oxytocin_and_vasopressin_receptor_modulators dbt:Systemic-hormonal-drug-stub |
| dcterms:subject |
dbc:Obstetric_drugs dbc:Oxytocin_receptor_agonists dbc:Peptides |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatObstetricDrugs yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:PhysicalEntity100001930 dbo:Drug yago:Substance100020090 umbel-rc:ChemicalSubstanceType |
| rdfs:comment |
Demoxytocin (INN) (brand names Sandopart, Odeax, Sandopral), also known as desaminooxytocin or deaminooxytocin, as well as 1-(3-mercaptopropanoic acid)oxytocin ([Mpa1]OT), is an oxytocic peptide drug that is used to induce labor, promote lactation, and to prevent and treat puerperal (postpartum) mastitis (breast inflammation). Demoxytocin is a synthetic analogue of oxytocin and has similar activities, but is more potent and has a longer half-life in comparison. Unlike oxytocin, which is given via intravenous injection, demoxytocin is administered as a buccal tablet formulation. (en) |
| rdfs:label |
Demoxytocin (en) |
| owl:sameAs |
freebase:Demoxytocin yago-res:Demoxytocin wikidata:Demoxytocin dbpedia-sh:Demoxytocin dbpedia-sr:Demoxytocin https://global.dbpedia.org/id/4it8H |
| prov:wasDerivedFrom |
wikipedia-en:Demoxytocin?oldid=992957493&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Demoxytocin.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Demoxytocin |
| is dbo:wikiPageRedirects of |
dbr:Sandopart dbr:Sandopral dbr:Odeax dbr:C43H65N11O12S2 dbr:ATC_code_H01BB01 dbr:ATCvet_code_QH01BB01 dbr:Desamino-Oxytocin dbr:Desamino-oxytocin dbr:Desaminooxytocin dbr:Deamino-Oxytocin dbr:Deamino-oxytocin dbr:Deaminooxytocin dbr:ODA-914 dbr:ODA914 dbr:ODA_914 |
| is dbo:wikiPageWikiLink of |
dbr:List_of_compounds_with_carbon_numbers_40–49 dbr:Sandopart dbr:Sandopral dbr:Odeax dbr:C43H65N11O12S2 dbr:Lipo-oxytocin-1 dbr:Oxytocin_receptor dbr:ATC_code_H01BB01 dbr:ATCvet_code_QH01BB01 dbr:ATC_code_H01 dbr:Merotocin dbr:Uterotonic dbr:List_of_drugs:_De dbr:Desamino-Oxytocin dbr:Desamino-oxytocin dbr:Desaminooxytocin dbr:Deamino-Oxytocin dbr:Deamino-oxytocin dbr:Deaminooxytocin dbr:ODA-914 dbr:ODA914 dbr:ODA_914 |
| is foaf:primaryTopic of |
wikipedia-en:Demoxytocin |
