Dermal equivalent (original) (raw)
The dermal equivalent, also known as dermal replacement or neodermis, is an in vitro model of the dermal layer of skin. There is no specific way of forming a dermal equivalent, however the first dermal equivalent was constructed by seeding dermal fibroblasts into a collagen gel. This gel may then be allowed to contract as a model of wound contraction. This collagen gel contraction assay may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a scar. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, keratinocytes may be seeded on the surface to create a skin equivalent, or macrophages may be incorporated to model the inflammatory phase of wound healing.
| Property | Value |
|---|---|
| dbo:abstract | The dermal equivalent, also known as dermal replacement or neodermis, is an in vitro model of the dermal layer of skin. There is no specific way of forming a dermal equivalent, however the first dermal equivalent was constructed by seeding dermal fibroblasts into a collagen gel. This gel may then be allowed to contract as a model of wound contraction. This collagen gel contraction assay may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a scar. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, keratinocytes may be seeded on the surface to create a skin equivalent, or macrophages may be incorporated to model the inflammatory phase of wound healing. A number of commercial dermal equivalents with different compositions and development methods are available. These include Integra, AlloDerm, and Dermagraft, among others. (en) |
| dbo:wikiPageExternalLink | https://www.integralife.com/home https://dermagraft.com https://hcp.alloderm.com |
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| dbo:wikiPageLength | 13290 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1070324629 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Ross_Granville_Harrison dbr:Dermal_fibroblast dbr:Dermis dbr:In_vitro dbr:Eschar dbr:Silastic dbr:Gingival_grafting dbr:Glutaraldehyde dbr:Macrophages dbr:Cadaver dbr:Chondroitin_sulfate dbr:Autotransplantation dbr:John_F._Burke dbr:Oculoplastics dbr:Diabetic_foot_ulcer dbr:Wound_contraction dbr:Regeneration_in_humans dbr:Regenerative_medicine dbr:Acellular_dermis dbc:Skin_physiology dbr:Keratinocytes dbr:Collagen dbr:Collagen_gel_contraction_assay dbr:Artificial_skin dbr:Fibroblast dbr:Integra_LifeSciences dbr:Scar dbr:Skin_equivalent dbr:Wound_healing dbr:Tissue_engineering dbr:Polyglactin dbr:Polysiloxane dbr:Extracellular_matrix_proteins |
| dbp:wikiPageUsesTemplate | dbt:Reflist |
| dct:subject | dbc:Skin_physiology |
| rdfs:comment | The dermal equivalent, also known as dermal replacement or neodermis, is an in vitro model of the dermal layer of skin. There is no specific way of forming a dermal equivalent, however the first dermal equivalent was constructed by seeding dermal fibroblasts into a collagen gel. This gel may then be allowed to contract as a model of wound contraction. This collagen gel contraction assay may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a scar. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, keratinocytes may be seeded on the surface to create a skin equivalent, or macrophages may be incorporated to model the inflammatory phase of wound healing. (en) |
| rdfs:label | Dermal equivalent (en) |
| owl:sameAs | freebase:Dermal equivalent wikidata:Dermal equivalent https://global.dbpedia.org/id/4iSrB |
| prov:wasDerivedFrom | wikipedia-en:Dermal_equivalent?oldid=1070324629&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Dermal_equivalent |
| is dbo:wikiPageRedirects of | dbr:Dermal_replacement dbr:Neodermis |
| is dbo:wikiPageWikiLink of | dbr:Collagen_gel_contraction_assay dbr:Skin_equivalent dbr:Wound_healing dbr:Dermal_replacement dbr:Neodermis |
| is foaf:primaryTopic of | wikipedia-en:Dermal_equivalent |