| dbo:abstract |
Dirlotapide is a drug used to treat obesity in dogs. It is manufactured by Pfizer and Zoetis and marketed under the brand name Slentrol. It works as a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor. This blocks the assembly and release of lipoproteins into the bloodstream, thereby reducing fat absorption. It also elicits a satiety signal from lipid-filled cells lining the intestine. (en) |
| dbo:alternativeName |
Slentrol (en) |
| dbo:casNumber |
481658-94-0 |
| dbo:chEMBL |
410414 |
| dbo:fdaUniiCode |
578H0RMP25 |
| dbo:kegg |
D03867 |
| dbo:pubchem |
9917862 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Dirlotapide_structure.svg?width=300 |
| dbo:wikiPageID |
8775736 (xsd:integer) |
| dbo:wikiPageLength |
6488 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1076207157 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Pfizer dbc:Acetamides dbc:Biphenyls dbc:Indoles dbc:Trifluoromethyl_compounds dbr:Zoetis dbr:Lipoprotein dbc:Benzamides dbr:European_Medicines_Agency dbr:Food_and_Drug_Administration_(United_States) dbc:Antiobesity_drugs dbr:Hunger dbr:Dog_breed dbc:Dog_medications dbr:Microsomal_triglyceride_transfer_protein |
| dbp:atcPrefix |
A08 (en) |
| dbp:atcSuffix |
AB91 (en) |
| dbp:atcvet |
yes (en) |
| dbp:c |
40 (xsd:integer) |
| dbp:casNumber |
481658 (xsd:integer) |
| dbp:chembl |
410414 (xsd:integer) |
| dbp:chemspiderid |
8093509 (xsd:integer) |
| dbp:eliminationHalfLife |
-64800.0 (dbd:second) |
| dbp:excretion |
Feces, urine (en) |
| dbp:f |
3 (xsd:integer) |
| dbp:h |
33 (xsd:integer) |
| dbp:image |
Dirlotapide ball-and-stick model.png (en) |
| dbp:iupacName |
1 (xsd:integer) |
| dbp:kegg |
D03867 (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:metabolism |
Hepatic (en) |
| dbp:n |
4 (xsd:integer) |
| dbp:o |
3 (xsd:integer) |
| dbp:proteinBound |
High (en) |
| dbp:pubchem |
9917862 (xsd:integer) |
| dbp:routesOfAdministration |
Oral (en) |
| dbp:smiles |
FCc1cccc2ccccc2CNc3cc4cnC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
TUOSYWCFRFNJBS-BHVANESWSA-N (en) |
| dbp:tradename |
Slentrol (en) |
| dbp:unii |
578 (xsd:integer) |
| dbp:verifiedrevid |
443642508 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:width |
260 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Drugs.com dbt:Antiobesity_preparations dbt:Lipid_modifying_agents |
| dct:subject |
dbc:Acetamides dbc:Biphenyls dbc:Indoles dbc:Trifluoromethyl_compounds dbc:Benzamides dbc:Antiobesity_drugs dbc:Dog_medications |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:Abstraction100002137 yago:Acetamide114711197 yago:Amide114724264 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Substance100019613 yago:WikicatAcetamides umbel-rc:DrugProduct |
| rdfs:comment |
Dirlotapide is a drug used to treat obesity in dogs. It is manufactured by Pfizer and Zoetis and marketed under the brand name Slentrol. It works as a gut-selective microsomal triglyceride transfer protein (MTTP or MTP) inhibitor. This blocks the assembly and release of lipoproteins into the bloodstream, thereby reducing fat absorption. It also elicits a satiety signal from lipid-filled cells lining the intestine. (en) |
| rdfs:label |
Dirlotapide (en) |
| owl:sameAs |
freebase:Dirlotapide yago-res:Dirlotapide wikidata:Dirlotapide dbpedia-sh:Dirlotapide dbpedia-sr:Dirlotapide dbpedia-th:Dirlotapide https://global.dbpedia.org/id/4j1bR |
| prov:wasDerivedFrom |
wikipedia-en:Dirlotapide?oldid=1076207157&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Dirlotapide_ball-and-stick_model.png wiki-commons:Special:FilePath/Dirlotapide_structure.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Dirlotapide |
| is dbo:wikiPageRedirects of |
dbr:C40H33F3N4O3 dbr:ATCvet_code_QA08AB91 dbr:Slentrol |
| is dbo:wikiPageWikiLink of |
dbr:Zoetis dbr:C40H33F3N4O3 dbr:ATCvet_code_QA08AB91 dbr:ATC_code_A08 dbr:Mitratapide dbr:Microsomal_triglyceride_transfer_protein dbr:Obesity_in_pets dbr:List_of_drugs:_Df–Di dbr:Slentrol |
| is foaf:primaryTopic of |
wikipedia-en:Dirlotapide |
